LIPOPROTEINS, NEUROBIOLOGY, AND ALZHEIMERS-DISEASE - STRUCTURE AND FUNCTION OF APOLIPOPROTEIN-E

被引：56

作者：

WEISGRABER, KH

PITAS, RE

MAHLEY, RW

机构：

[1] KH Weisgraber and RE Pitas, Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94141-9100

[2] Department of Pathology, University of California, San Francisco

[3] RW Mahley, Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94141-9100

[4] Departments of Medicine and Pathology, University of California, San Francisco

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1994年 / 4卷 / 04期

关键词：

D O I：

10.1016/S0959-440X(94)90212-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure of apolipoprotein E has provided unique insights into the role of this protein in lipoprotein metabolism and neurobiology. Isoform-specific differences between apolipoprotein E3 and apolipoprotein E4 have been described with respect to neurite extension by cultured neurons, and interactions with proteins characteristic of the lesions of Alzheimer's disease, such as the amyloid beta peptide of neuritic plaques and tau, the microtubule-associated protein of neurofibrillary tangles. Apolipoprotein E may play a part in normal neurobiology and in the pathogenesis of Alzheimer's disease.

引用

页码：507 / 515

页数：9

共 50 条

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AGGERBECK LP, 1988, J BIOL CHEM, V263, P6249

[2] APOLIPOPROTEIN-E IMMUNOREACTIVE DEPOSITS IN INCLUSION-BODY MUSCLE DISEASES [J].