TAU-PROTEIN AND PAIRED HELICAL FILAMENTS OF ALZHEIMERS-DISEASE

被引：30

作者：

CROWTHER, RA ^{[1
]}

机构：

[1] MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1993年 / 3卷 / 02期

关键词：

D O I：

10.1016/S0959-440X(05)80153-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Significant advances have recently been made in understanding the nature of the Alzheimer paired helical filament. This appears to consist entirely of abnormally phosphorylated microtubule-associated protein Tau. Filaments resembling those found in Alzheimer's disease have been assembled in vitro from fragments of Tau protein spanning the microtubule-binding repeat region.

引用

页码：202 / 206

页数：5

共 25 条

[1] NEUROFIBRILLARY TANGLES BUT NOT SENILE PLAQUES PARALLEL DURATION AND SEVERITY OF ALZHEIMERS-DISEASE
ARRIAGADA, PV
GROWDON, JH
HEDLEYWHYTE, ET
HYMAN, BT
[J]. NEUROLOGY, 1992, 42 (03) : 631 - 639
[2] THE SWITCH OF TAU-PROTEIN TO AN ALZHEIMER-LIKE STATE INCLUDES THE PHOSPHORYLATION OF 2 SERINE PROLINE MOTIFS UPSTREAM OF THE MICROTUBULE BINDING REGION
BIERNAT, J
MANDELKOW, EM
SCHROTER, C
LICHTENBERGKRAAG, B
STEINER, B
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MEYER, H
MERCKEN, M
VANDERMEEREN, A
GOEDERT, M
MANDELKOW, E
[J]. EMBO JOURNAL, 1992, 11 (04) : 1593 - 1597
[3] A68 PROTEINS IN ALZHEIMERS-DISEASE ARE COMPOSED OF SEVERAL TAU ISOFORMS IN A PHOSPHORYLATED STATE WHICH AFFECTS THEIR ELECTROPHORETIC MOBILITIES
BRION, JP
HANGER, DP
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ANDERTON, BH
[J]. BIOCHEMICAL JOURNAL, 1991, 279 : 831 - 836
[4] TAU-PROTEIN BINDS TO MICROTUBULES THROUGH A FLEXIBLE ARRAY OF DISTRIBUTED WEAK SITES
BUTNER, KA
KIRSCHNER, MW
[J]. JOURNAL OF CELL BIOLOGY, 1991, 115 (03) : 717 - 730
[5] STRAIGHT AND PAIRED HELICAL FILAMENTS IN ALZHEIMER-DISEASE HAVE A COMMON STRUCTURAL UNIT
CROWTHER, RA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (06) : 2288 - 2292
[6] THE MICROTUBULE BINDING REPEATS OF TAU PROTEIN ASSEMBLE INTO FILAMENTS LIKE THOSE FOUND IN ALZHEIMERS-DISEASE
CROWTHER, RA
OLESEN, OF
JAKES, R
GOEDERT, M
[J]. FEBS LETTERS, 1992, 309 (02) : 199 - 202
[7] IMAGE-RECONSTRUCTION OF THE ALZHEIMER PAIRED HELICAL FILAMENT
CROWTHER, RA
WISCHIK, CM
[J]. EMBO JOURNAL, 1985, 4 (13B) : 3661 - 3665
[8] MODULATION OF THE DYNAMIC INSTABILITY OF TUBULIN ASSEMBLY BY THE MICROTUBULE-ASSOCIATED PROTEIN TAU
DRECHSEL, DN
HYMAN, AA
COBB, MH
KIRSCHNER, MW
[J]. MOLECULAR BIOLOGY OF THE CELL, 1992, 3 (10) : 1141 - 1154
[9] MITOGEN ACTIVATED PROTEIN (MAP) KINASE TRANSFORMS TAU-PROTEIN INTO AN ALZHEIMER-LIKE STATE
DREWES, G
LICHTENBERGKRAAG, B
DORING, F
MANDELKOW, EM
BIERNAT, J
GORIS, J
DOREE, M
MANDELKOW, E
[J]. EMBO JOURNAL, 1992, 11 (06) : 2131 - 2138
[10] MOLECULAR CHARACTERIZATION OF MICROTUBULE-ASSOCIATED PROTEINS-TAU AND MAP2
GOEDERT, M
CROWTHER, RA
GARNER, CC
[J]. TRENDS IN NEUROSCIENCES, 1991, 14 (05) : 193 - 199

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