TAU-PROTEIN AND PAIRED HELICAL FILAMENTS OF ALZHEIMERS-DISEASE

被引：30

作者：

CROWTHER, RA ^{[1
]}

机构：

[1] MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1993年 / 3卷 / 02期

关键词：

D O I：

10.1016/S0959-440X(05)80153-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Significant advances have recently been made in understanding the nature of the Alzheimer paired helical filament. This appears to consist entirely of abnormally phosphorylated microtubule-associated protein Tau. Filaments resembling those found in Alzheimer's disease have been assembled in vitro from fragments of Tau protein spanning the microtubule-binding repeat region.

引用

页码：202 / 206

页数：5

共 25 条

[11] CLONING AND SEQUENCING OF THE CDNA-ENCODING A CORE PROTEIN OF THE PAIRED HELICAL FILAMENT OF ALZHEIMER-DISEASE - IDENTIFICATION AS THE MICROTUBULE-ASSOCIATED PROTEIN TAU
GOEDERT, M
WISCHIK, CM
CROWTHER, RA
WALKER, JE
KLUG, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (11) : 4051 - 4055
[12] TAU-PROTEINS OF ALZHEIMER PAIRED HELICAL FILAMENTS - ABNORMAL PHOSPHORYLATION OF ALL 6 BRAIN ISOFORMS
GOEDERT, M
SPILLANTINI, MG
CAIRNS, NJ
CROWTHER, RA
[J]. NEURON, 1992, 8 (01) : 159 - 168
[13] Goedert M, 1991, Curr Opin Neurobiol, V1, P441, DOI 10.1016/0959-4388(91)90067-H
[14] P42 MAP KINASE PHOSPHORYLATION SITES IN MICROTUBULE-ASSOCIATED PROTEIN TAU ARE DEPHOSPHORYLATED BY PROTEIN PHOSPHATASE-2A1 - IMPLICATIONS FOR ALZHEIMERS-DISEASE
GOEDERT, M
COHEN, ES
JAKES, R
COHEN, P
[J]. FEBS LETTERS, 1992, 312 (01): : 95 - 99
[15] GREENBERG SG, 1992, J BIOL CHEM, V267, P564
[16] A PREPARATION OF ALZHEIMER PAIRED HELICAL FILAMENTS THAT DISPLAYS DISTINCT TAU-PROTEINS BY POLYACRYLAMIDE-GEL ELECTROPHORESIS
GREENBERG, SG
DAVIES, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (15) : 5827 - 5831
[17] THE ALZHEIMER-LIKE PHOSPHORYLATION OF TAU-PROTEIN REDUCES MICROTUBULE BINDING AND INVOLVES SER-PRO AND THR-PRO MOTIFS
GUSTKE, N
STEINER, B
MANDELKOW, EM
BIERNAT, J
MEYER, HE
GOEDERT, M
MANDELKOW, E
[J]. FEBS LETTERS, 1992, 307 (02): : 199 - 205
[18] HASEGAWA M, 1992, J BIOL CHEM, V267, P17047
[19] IDENTIFICATION OF 3-REPEAT AND 4-REPEAT TAU-ISOFORMS WITHIN THE PHF IN ALZHEIMERS-DISEASE
JAKES, R
NOVAK, M
DAVISON, M
WISCHIK, CM
[J]. EMBO JOURNAL, 1991, 10 (10) : 2725 - 2729
[20] MICROTUBULE BUNDLING BY TAU PROTEINS INVIVO - ANALYSIS OF FUNCTIONAL DOMAINS
KANAI, Y
CHEN, JG
HIROKAWA, N
[J]. EMBO JOURNAL, 1992, 11 (11) : 3953 - 3961

← 1 2 3 →