A NEW TOOL FOR STUDYING PROTEIN-STRUCTURE AND FUNCTION

被引：28

作者：

CORNISH, VW

SCHULTZ, PG

机构：

[1] University of California, Berkeley

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1994年 / 4卷 / 04期

关键词：

D O I：

10.1016/S0959-440X(94)90224-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A technique that allows for the site-specific incorporation of a large variety of unnatural amino acids into proteins has been developed. This methodology has been used to substitute amino acids with novel electronic, steric. and spectroscopic properties into proteins, providing new insights into the mechanisms of protein stability, enzymatic catalysis and signal transduction.

引用

页码：601 / 607

页数：7

共 69 条

[61] SPANDIDOS D. A., 1989, RAS ONCOGENES
[62] PHOTOLYSIS AND DEACYLATION OF INHIBITED CHYMOTRYPSIN
STODDARD, BL
BRUHNKE, J
KOENIGS, P
PORTER, N
RINGE, D
PETSKO, GA
[J]. BIOCHEMISTRY, 1990, 29 (35) : 8042 - 8051
[63] A CYTOPLASMIC PROTEIN STIMULATES NORMAL N-RAS P21 GTPASE, BUT DOES NOT AFFECT ONCOGENIC MUTANTS
TRAHEY, M
MCCORMICK, F
[J]. SCIENCE, 1987, 238 (4826) : 542 - 545
[64] TUCKER PW, 1979, MOL CELL BIOCHEM, V23, P3
[65] DIVERSE INTERACTIONS BETWEEN THE INDIVIDUAL MUTATIONS IN A DOUBLE MUTANT AT THE ACTIVE-SITE OF STAPHYLOCOCCAL NUCLEASE
WEBER, DJ
SERPERSU, EH
SHORTLE, D
MILDVAN, AS
[J]. BIOCHEMISTRY, 1990, 29 (37) : 8632 - 8642
[66] INTERACTIONS OF THE ACID AND BASE CATALYSTS ON STAPHYLOCOCCAL NUCLEASE AS STUDIED IN A DOUBLE MUTANT
WEBER, DJ
MEEKER, AK
MILDVAN, AS
[J]. BIOCHEMISTRY, 1991, 30 (25) : 6103 - 6114
[67] BARRIERS TO ROTATION ADJACENT TO DOUBLE-BONDS .3. THE C-O BARRIER IN FORMIC-ACID, METHYL FORMATE, ACETIC-ACID, AND METHYL ACETATE - THE ORIGIN OF ESTER AND AMIDE RESONANCE
WIBERG, KB
LAIDIG, KE
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (20) : 5935 - 5943
[68] PREDICTION OF THE OCCURRENCE OF THE ADP-BINDING BETA-ALPHA-BETA-FOLD IN PROTEINS, USING AN AMINO-ACID-SEQUENCE FINGERPRINT
WIERENGA, RK
TERPSTRA, P
HOL, WGJ
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1986, 187 (01) : 101 - 107
[69] DEPENDENCE OF CONFORMATIONAL STABILITY ON HYDROPHOBICITY OF THE AMINO-ACID RESIDUE IN A SERIES OF VARIANT PROTEINS SUBSTITUTED AT A UNIQUE POSITION OF TRYPTOPHAN SYNTHASE ALPHA-SUBUNIT
YUTANI, K
OGASAHARA, K
TSUJITA, T
SUGINO, Y
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (13) : 4441 - 4444

← 1 2 3 4 5 6 7 →