HLA CLASS-II TYPING AND IDIOPATHIC IGA NEPHROPATHY (IGAN) - DQB1-ASTERISK-0301, A POSSIBLE MARKER OF UNFAVORABLE OUTCOME

被引：27

作者：

RAGUENES, O

MERCIER, B

CLEDES, J

WHEBE, B

FEREC, C

机构：

[1] CTR DEPT TRANSFUS SANGUINE, CTR BIOGENET, F-29275 BREST, FRANCE

[2] CTR HOSP REG & UNIV MORVAN, SERV NEPHROL, BREST, FRANCE

[3] CTR HOSP QUIMPER, SERV NEPHROL, QUIMPER, FRANCE

来源：

TISSUE ANTIGENS | 1995年 / 45卷 / 04期

关键词：

HLA CLASS II TYPING; IDIOPATHIC IGA NEPHROPATHY (IGAN); DQB1-ASTERISK-0301;

D O I：

10.1111/j.1399-0039.1995.tb02447.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Previous studies have reported associations between HLA antigens and Idiopathic IgA Nephropathy (IgAN). Nevertheless most of the studies were performed by serology. Thus we decided to perform the HLA class II typing of 58 patients by molecular biology techniques. We report a small increase of DRB1*04. But the main result of our study is the identification of a strong association between HLA DQB1*0301 and IgAN patients with an unfavorable outcome.

引用

页码：246 / 249

页数：4

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