OMEGA-CONOTOXIN MVIIC REVERSIBLY INHIBITS A HUMAN N-TYPE CALCIUM-CHANNEL AND CALCIUM INFLUX INTO CHICK SYNAPTOSOMES

被引：52

作者：

GRANTHAM, CJ

BOWMAN, D

BATH, CP

BELL, DC

BLEAKMAN, D

机构：

[1] Lilly Research Centre Ltd, Windlesham, Surrey GU20 6PH, Erl Wood Manor

来源：

NEUROPHARMACOLOGY | 1994年 / 33卷 / 02期

关键词：

OMEGA-CONOTOXIN MVIIC; ALPHA(1B) SUBUNIT; N-TYPE CALCIUM CHANNEL; CALCIUM INFLUX; CHICK SYNAPTOSOMES;

D O I：

10.1016/0028-3908(94)90017-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have investigated the effects of omega-CmTX MVIIC on the recombinant alpha(1B)-mediated calcium channel expressed in HEK 293 cells and on the predominantly N-type calcium channel in chick synaptosomes. omega-CmTX MVIIC potently and reversibly inhibited the calcium current through alpha(1B)-mediated calcium channels and inhibited KCl-evoked increases in [Ca2+](i) in chick synaptosomes in a concentration-dependent manner.

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收藏

页码：255 / 258

页数：4

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