AEROSOLIZED PROSTACYCLIN FOR PULMONARY-HYPERTENSION IN NEONATES
被引:53
作者:
BINDL, L
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BINDL, L
FAHNENSTICH, H
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FAHNENSTICH, H
PEUKERT, U
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PEUKERT, U
机构:
来源:
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
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1994年
/
71卷
/
03期
关键词:
D O I:
10.1136/fn.71.3.F214
中图分类号:
R72 [儿科学];
学科分类号:
100202 ;
摘要:
Aerosolised prostacyclin (PGI(2)) was administered to two neonates with pulmonary hypertension to dilate the pulmonary vessels selectively. The alveolar-arterial oxygen gradient fell from 73.2 (patient 1) and 71.8 kPa (patient 2) to 33.8 and 26.7 kPa respectively. Systemic blood pressure remained stable while pulmonary blood pressure declined in patient 1. When inhaled, PGI(2) seems to improve oxygenation, mainly due to reduction of intrapulmonary shunting.