PROTEIN AND RNA-SYNTHESIS IN KAINIC ACID-INJECTED STRIATA

被引：6

作者：

JAKUBOVIC, A

LIN, D

MCGEER, EG

机构：

[1] Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver

来源：

BRAIN RESEARCH | 1979年 / 163卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0006-8993(79)90356-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Injections of kainic acid into rat neostriata destroy neuronal soma in the injected area. Kainic acid-injected neostriata show a significant increase (as compared with control) in the incorporation in vitro of label from radioactive leucine into the TCA-insoluble protein fraction at all time periods studied (from 1 to 80 days after the kainic acid injection), with the greatest stimulation (6-7-fold) occurring between the third and eighth day. At 1-5 days there was also increased incorporation in vitro of label from uridine into RNA. The increased protein synthesis is probably due to the astrocytes which invade the injected area and are still seen in electron microscopic studies 2-3 months after the injections. © 1979.

引用

页码：289 / 294

页数：6