EFFECT OF LIPOIC ACID ON CYCLOPHOSPHAMIDE-INDUCED DIABETES AND INSULITIS IN NONOBESE DIABETIC MICE

被引:28
作者
FAUST, A
BURKART, V
ULRICH, H
WEISCHER, CH
KOLB, H
机构
[1] UNIV DUSSELDORF,DIABET RES INST,W-4000 DUSSELDORF 1,GERMANY
[2] ASTA MEDICA AG,FRANKFURT,GERMANY
来源
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 1994年 / 16卷 / 01期
关键词
D O I
10.1016/0192-0561(94)90119-8
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In an animal model of type I diabetes, the non-obese diabetic (NOD) mouse, the influence of the antioxidant lipoic acid (LA) on the development of diabetes was investigated. Acceleration of diabetes development with cyclophosphamide (CY) resulted in 60% diabetic animals with severely infiltrated islets within 1 - 3 weeks. Daily administration of lipoic acid for 20 or 30 days around cyclophosphamide treatment suppressed the incidence of diabetes to 30% (P<0.05) and 33%, respectively. Semiquantitative analysis of islet infiltration showed a reduction of severe intraislet infiltration and an increase in the percentage of islets with mild peri-insular and periductular infiltrates (from 8.4 to 29.6 and 25.9%, respectively, P<0.01) after lipoic acid treatment. These results show that the protective effect of lipoic acid on diabetes development correlates with partial suppression of islet inflammation. The anti-inflammatory action of lipoic acid may be due to its ability to scavenge oxygen radicals and to suppress nitric oxide production.
引用
收藏
页码:61 / 66
页数:6
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