EFFECT OF LIPOIC ACID ON CYCLOPHOSPHAMIDE-INDUCED DIABETES AND INSULITIS IN NONOBESE DIABETIC MICE

被引：28

作者：

FAUST, A

BURKART, V

ULRICH, H

WEISCHER, CH

KOLB, H

机构：

[1] UNIV DUSSELDORF,DIABET RES INST,W-4000 DUSSELDORF 1,GERMANY

[2] ASTA MEDICA AG,FRANKFURT,GERMANY

来源：

INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 1994年 / 16卷 / 01期

关键词：

D O I：

10.1016/0192-0561(94)90119-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In an animal model of type I diabetes, the non-obese diabetic (NOD) mouse, the influence of the antioxidant lipoic acid (LA) on the development of diabetes was investigated. Acceleration of diabetes development with cyclophosphamide (CY) resulted in 60% diabetic animals with severely infiltrated islets within 1 - 3 weeks. Daily administration of lipoic acid for 20 or 30 days around cyclophosphamide treatment suppressed the incidence of diabetes to 30% (P<0.05) and 33%, respectively. Semiquantitative analysis of islet infiltration showed a reduction of severe intraislet infiltration and an increase in the percentage of islets with mild peri-insular and periductular infiltrates (from 8.4 to 29.6 and 25.9%, respectively, P<0.01) after lipoic acid treatment. These results show that the protective effect of lipoic acid on diabetes development correlates with partial suppression of islet inflammation. The anti-inflammatory action of lipoic acid may be due to its ability to scavenge oxygen radicals and to suppress nitric oxide production.

引用

页码：61 / 66

页数：6

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