OPENING OF 2',3'-O-ANHYDRO-RING OF 2',3'-O-ANHYDRO-LYXO-URIDINE BY ALKYLAMINES AND ARYLAMINES - EASY SYNTHESES AND PREPARATIVE USES OF 2'-DEOXY-2'-ALKYLAMINO-XYLO-URIDINES AND 3'-DEOXY-3'-ALKYLAMINO-ARA-URIDINES

被引：9

作者：

BERA, S

PATHAK, T

LANGLEY, GJ

机构：

[1] NATL CHEM LAB, DIV ORGAN CHEM SYNTH, POONA 411008, MAHARASHTRA, INDIA

[2] UNIV SOUTHAMPTON, DEPT CHEM, SOUTHAMPTON SO9 5NH, HANTS, ENGLAND

来源：

TETRAHEDRON | 1995年 / 51卷 / 05期

关键词：

D O I：

10.1016/0040-4020(94)01040-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Contrary to the previous report (ref. 8), under controlled conditions alkylamines, both primary and secondary and arylamines, opened the epoxide ring of 1-(5-0-trityl-2,3-O-anhydro-beta-D-lyxo-furanosyl)-uracil to produce 2'-deoxy-2'-alkylamino-xylo- and 3'-deoxy-3'-alkylaminoara- uridines without causing any significant deglycosylation. To show tire utility of these products, several modified uridine derivatives were synthesised.

引用

收藏

页码：1459 / 1470

页数：12

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