ACTIVATION OF C-KI-RAS NOT DETECTABLE IN ADENOMAS OR ADENOCARCINOMAS ARISING IN RAT PANCREAS

被引：38

作者：

SCHAEFFER, BK ^{[1
]}

ZURLO, J ^{[1
]}

LONGNECKER, DS ^{[1
]}

机构：

[1] DARTMOUTH COLL, HITCHCOCK MED CTR, DARTMOUTH MED SCH, DEPT PHARMACOL & TOXICOL, HANOVER, NH 03756 USA

来源：

MOLECULAR CARCINOGENESIS | 1990年 / 3卷 / 03期

关键词：

Key words; mutation; oncogene; Polymerase chain reaction;

D O I：

10.1002/mc.2940030310

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The objective of this study was to determine whether activation of c‐Ki‐ras occurs in carcinogen‐induced rat pancreatic tumors. DNAs from 27 samples, which included adenomas, carcinomas in situ, and adenocarcinomas arising in azaserine‐treated rats and corn oil‐gavaged rats along with a nafenopin‐induced rat pancreatic adenocarcinoma were examined for mutation of c‐Ki‐ras at codons 12, 13, and 61 by using the polymerase chain reaction. Our results indicate that activation of c‐Ki‐ras is not a common event during pancreatic carcinogenesis in the rat. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：165 / 170

页数：6

共 30 条

[11] LONGNECKER D S, 1988, Pancreas, V3, P605
[12] TRANSPLANTATION OF AZASERINE-INDUCED CARCINOMAS OF PANCREAS IN RATS
LONGNECKER, DS
LILJA, HS
FRENCH, J
KUHLMANN, E
NOLL, W
[J]. CANCER LETTERS, 1979, 7 (04) : 197 - 202
[13] LONGNECKER DS, 1987, EXPT PANCREATIC CARC, P243
[14] FREQUENCY AND TYPES OF POINT MUTATION AT THE 12TH CODON OF THE C-KI-RAS GENE FOUND IN PANCREATIC CANCERS FROM JAPANESE PATIENTS
MARIYAMA, M
KISHI, K
NAKAMURA, K
OBATA, H
NISHIMURA, S
[J]. JAPANESE JOURNAL OF CANCER RESEARCH, 1989, 80 (07): : 622 - 626
[15] OHARA BM, 1986, CANCER RES, V46, P4695
[16] PARSA I, 1988, INT J PANCREATOL, V3, P45
[17] HUMAN-TUMOR-DERIVED CELL-LINES CONTAIN COMMON AND DIFFERENT TRANSFORMING GENES
PERUCHO, M
GOLDFARB, M
SHIMIZU, K
LAMA, C
FOGH, J
WIGLER, M
[J]. CELL, 1981, 27 (03) : 467 - 476
[18] PANCREATIC NEOPLASIA INDUCED BY RAS EXPRESSION IN ACINAR-CELLS OF TRANSGENIC MICE
QUAIFE, CJ
PINKERT, CA
ORNITZ, DM
PALMITER, RD
BRINSTER, RL
[J]. CELL, 1987, 48 (06) : 1023 - 1034
[19] RAO MS, 1987, EXPT PANCREATIC CARC, P243
[20] DETECTION AND IDENTIFICATION OF ACTIVATED ONCOGENES IN SPONTANEOUSLY OCCURRING BENIGN AND MALIGNANT HEPATOCELLULAR TUMORS OF THE B6C3F1 MOUSE
REYNOLDS, SH
STOWERS, SJ
MARONPOT, RR
ANDERSON, MW
AARONSON, SA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (01) : 33 - 37

← 1 2 3 →