STRESS AND THE MEMORY T-CELL RESPONSE TO THE EPSTEIN-BARR-VIRUS IN HEALTHY MEDICAL-STUDENTS

被引：97

作者：

GLASER, R

PEARSON, GR

BONNEAU, RH

ESTERLING, BA

ATKINSON, C

KIECOLTGLASER, JK

机构：

[1] Department of Medical Microbiology and Immunology, Comprehensive Cancer Center, Ohio State University College of Medicine

[2] Department of Microbiology, Georgetown University

[3] Department of Psychiatry, Ohio State University College of Medicine

来源：

HEALTH PSYCHOLOGY | 1993年 / 12卷 / 06期

关键词：

STRESS; SUPPORT SEEKING; EPSTEIN-BARR VIRUS; BLASTOGENESIS;

D O I：

10.1037/0278-6133.12.6.435

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

This study investigated the memory T-cell proliferative response to several early and late Epstein-Barr virus (EBV) polypeptides. Blood samples were collected twice, 1 month before a 3-day block of examinations and again on the last day of the exam series. Ss were 25 healthy. EBV seropositive medical students. The proliferative response to 5 of the 6 EBV polypeptides significantly decreased during examinations. In addition, Ss high (above the median) in seeking support, as measured by the COPE, had tower proliferative responses to 3 EBV polypeptides (p17, p52/50, and p85), as well as higher levels of antibody to EBV virus capsid antigen. The data provide further evidence that psychological stress can modulate the cellular immune response to latent EBV.

引用

页码：435 / 442

页数：8

共 57 条

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