MECHANISMS OF ETHANOL TOLERANCE AT A CHOLINERGIC NERVE-TERMINAL

被引：7

作者：

CURRAN, M

SEEMAN, P

机构：

[1] Department of Pharmacology, University of Toronto, Toronto

来源：

DRUG AND ALCOHOL DEPENDENCE | 1979年 / 4卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0376-8716(79)90062-0

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

In vitro rat phrenic nerve-diaphragm preparations illustrated a concentration-dependent increase in the spontaneous release (miniature end-plate potentials, MEPPs) of acetylcholine following acute administration of ethanol. In phrenic nerve terminals from rats subjected to long-term ethanol treatment, ethanol in vitro was significantly less effective in increasing the frequency of MEPPs. The capacity of ethanol administration to change membrane viscosity and alter sequestration of intracellular Ca2+ is discussed as a possible explanation for the observed effects. © 1979.

引用

页码：167 / 172

页数：6

共 25 条

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[12]

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[13]

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