ENGINEERED HERPES-SIMPLEX VIRUS-DNA POLYMERASE POINT MUTANTS - THE MOST HIGHLY CONSERVED REGION SHARED AMONG ALPHA-LIKE DNA-POLYMERASES IS INVOLVED IN SUBSTRATE RECOGNITION

被引:61
作者
MARCY, AI [1 ]
HWANG, CBC [1 ]
RUFFNER, KL [1 ]
COEN, DM [1 ]
机构
[1] HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115
关键词
D O I
10.1128/JVI.64.12.5883-5890.1990
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
引用
收藏
页码:5883 / 5890
页数:8
相关论文
共 50 条
  • [1] PRIMARY STRUCTURAL RELATIONSHIPS MAY REFLECT SIMILAR DNA-REPLICATION STRATEGIES
    ARGOS, P
    TUCKER, AD
    PHILIPSON, L
    [J]. VIROLOGY, 1986, 149 (02) : 208 - 216
  • [2] A SEQUENCE MOTIF IN MANY POLYMERASES
    ARGOS, P
    [J]. NUCLEIC ACIDS RESEARCH, 1988, 16 (21) : 9909 - 9916
  • [3] DNA-SEQUENCE AND EXPRESSION OF THE B95-8 EPSTEIN-BARR VIRUS GENOME
    BAER, R
    BANKIER, AT
    BIGGIN, MD
    DEININGER, PL
    FARRELL, PJ
    GIBSON, TJ
    HATFULL, G
    HUDSON, GS
    SATCHWELL, SC
    SEGUIN, C
    TUFFNELL, PS
    BARRELL, BG
    [J]. NATURE, 1984, 310 (5974) : 207 - 211
  • [4] Becker Y, 1988, Virus Genes, V1, P351
  • [5] A CONSERVED 3'-]5' EXONUCLEASE ACTIVE-SITE IN PROKARYOTIC AND EUKARYOTIC DNA-POLYMERASES
    BERNAD, A
    BLANCO, L
    LAZARO, JM
    MARTIN, G
    SALAS, M
    [J]. CELL, 1989, 59 (01) : 219 - 228
  • [6] THE HIGHLY CONSERVED AMINO-ACID-SEQUENCE MOTIF TYR-GLY-ASP-THR-ASP-SER IN ALPHA-LIKE DNA-POLYMERASES IS REQUIRED BY PHAGE-PHI-29 DNA-POLYMERASE FOR PROTEIN-PRIMED INITIATION AND POLYMERIZATION
    BERNAD, A
    LAZARO, JM
    SALAS, M
    BLANCO, L
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (12) : 4610 - 4614
  • [7] STRUCTURE AND FUNCTION OF THE SACCHAROMYCES-CEREVISIAE CDC2 GENE ENCODING THE LARGE SUBUNIT OF DNA POLYMERASE-III
    BOULET, A
    SIMON, M
    FAYE, G
    BAUER, GA
    BURGERS, PMJ
    [J]. EMBO JOURNAL, 1989, 8 (06) : 1849 - 1854
  • [8] MUTATIONS IN THE HERPES-SIMPLEX VIRUS MAJOR DNA-BINDING PROTEIN GENE LEADING TO ALTERED SENSITIVITY TO DNA-POLYMERASE INHIBITORS
    CHIOU, HC
    WELLER, SK
    COEN, DM
    [J]. VIROLOGY, 1985, 145 (02) : 213 - 226
  • [9] Chou P Y, 1978, Adv Enzymol Relat Areas Mol Biol, V47, P45
  • [10] MUTATIONS IN THE HERPES-SIMPLEX VIRUS-DNA POLYMERASE GENE CONFERRING HYPERSENSITIVITY TO APHIDICOLIN
    COEN, DM
    FURMAN, PA
    ASCHMAN, DP
    SCHAFFER, PA
    [J]. NUCLEIC ACIDS RESEARCH, 1983, 11 (15) : 5287 - 5297