ENGINEERED HERPES-SIMPLEX VIRUS-DNA POLYMERASE POINT MUTANTS - THE MOST HIGHLY CONSERVED REGION SHARED AMONG ALPHA-LIKE DNA-POLYMERASES IS INVOLVED IN SUBSTRATE RECOGNITION

被引：61

作者：

MARCY, AI ^{[1
]}

HWANG, CBC ^{[1
]}

RUFFNER, KL ^{[1
]}

COEN, DM ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115

来源：

JOURNAL OF VIROLOGY | 1990年 / 64卷 / 12期

关键词：

D O I：

10.1128/JVI.64.12.5883-5890.1990

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

引用

页码：5883 / 5890

页数：8

共 50 条

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[12] 2 DISTINCT LOCI CONFER RESISTANCE TO ACYCLOGUANOSINE IN HERPES-SIMPLEX VIRUS TYPE-1
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[13] MUTATIONS IN THE HERPES-SIMPLEX VIRUS-DNA POLYMERASE GENE CAN CONFER RESISTANCE TO 9-BETA-D-ARABINOFURANOSYLADENINE
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[14] FINE MAPPING AND MOLECULAR-CLONING OF MUTATIONS IN THE HERPES-SIMPLEX VIRUS-DNA POLYMERASE LOCUS
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[15] CHARACTERIZATION OF A DNA-POLYMERASE MUTANT OF HERPES-SIMPLEX VIRUS FROM A SEVERELY IMMUNOCOMPROMISED PATIENT RECEIVING ACYCLOVIR
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[16] INHIBITION OF HERPES-SIMPLEX VIRUS-INDUCED DNA-POLYMERASE, CELLULAR DNA POLYMERASE-ALPHA AND VIRUS PRODUCTION BY APHIDICOLIN
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[17] SITE-SPECIFIC MUTAGENESIS OF A HIGHLY CONSERVED REGION OF THE HERPES-SIMPLEX VIRUS TYPE-1 DNA-POLYMERASE GENE
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[J]. JOURNAL OF VIROLOGY, 1990, 64 (03) : 1394 - 1397
[18] HOMOLOGY BETWEEN DNA-POLYMERASES OF POXVIRUSES, HERPESVIRUSES, AND ADENOVIRUSES - NUCLEOTIDE-SEQUENCE OF THE VACCINIA VIRUS-DNA POLYMERASE GENE
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[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (11) : 3659 - 3663
[19] FRANK KB, 1984, J BIOL CHEM, V259, P3282
[20] INHIBITION OF HERPES-SIMPLEX VIRUS-INDUCED DNA-POLYMERASE ACTIVITY AND VIRAL-DNA REPLICATION BY 9-(2-HYDROXYETHOXYMETHYL)GUANINE AND ITS TRIPHOSPHATE
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