ASYMMETRIC-SYNTHESIS BY THE CN(R,S) METHOD .27. 1ST ASYMMETRIC-SYNTHESIS OF CARNOSADINE

被引：26

作者：

AITKEN, DJ ^{[1
]}

GUILLAUME, D ^{[1
]}

HUSSON, HP ^{[1
]}

机构：

[1] FAC SCI PHARMACEUT & BIOL PARIS,CHIM THERAPEUT LAB,CNRS,URA 1310,4 AVE OBSERV,F-75270 PARIS 06,FRANCE

来源：

TETRAHEDRON | 1993年 / 49卷 / 29期

关键词：

D O I：

10.1016/S0040-4020(01)80152-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first asymmetric synthesis of the naturally-occurring cyclopropane amino acid carnosadine, 1, has been carried out. Starting from the previously available chiral intermedia 2, appropriate amine protection and side-chain modifications permitted introduction of the key guanidyl substituent in a short and efficient synthesis to give the title compound in five steps and 45% overall yield.

引用

页码：6375 / 6380

页数：6