INCREASED SENSITIVITY TO AGONIST STIMULATION OF THE CA2+ RESPONSE IN NEUTROPHILS OF MANIC-DEPRESSIVE PATIENTS - EFFECT OF LITHIUM-THERAPY

被引:45
作者
VANCALKER, D
FORSTNER, U
BOHUS, M
GEBICKEHARTER, P
HECHT, H
WARK, HJ
BERGER, M
机构
[1] Department of Psychiatry, University of Freiburg
关键词
MANIC-DEPRESSIVE DISORDER; SIGNAL TRANSDUCTION; FORMYLMETHIONYLLEUCYLPHENYLALANINE; NEUTROPHILS;
D O I
10.1159/000118977
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The agonist-stimulated increase of intracellular free-Ca2+ concentration, an indicator of the sensitivity of the inositol phospholipid second-messenger generating system, was measured in neutrophils from patients with manic-depressive disorder, and controls. Dose-response curves of the calcium response were determined by measuring the fluorescence of neutrophils loaded with fura-2 and stimulated with various concentrations of the chemotactic tripeptide formylmethionylleucylphenylalanine. EC50 values were obtained for 14 medication-free patients (5 acutely depressive, and 9 symptom free remitted patients with a history of manic-depression or recurrent major depression), 9 lithium-treated, euthymic manic-depressive patients and 10 drug-free healthy controls. The EC50 values of the untreated patients were significantly lower than in the controls. Lithium-treated patients had EC50 values significantly higher than controls. These results suggest that manic-depressive disorder is associated with an increased sensitivity of the inositol phospholipid second-messenger generating system, which is counteracted by lithium treatment.
引用
收藏
页码:180 / 183
页数:4
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