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SOME NEW DEVELOPMENTS IN REDUCTIVE AMINATION WITH COFACTOR REGENERATION

被引：49
作者：
BOMMARIUS, AS
DRAUZ, K
HUMMEL, W
KULA, MR
WANDREY, C
机构：
[1] UNIV DUSSELDORF, INST ENZYMTECHNOL, D-52404 JULICH, GERMANY
[2] FORSCHUNGSZENTRUM JULICH, FORSCHUNGSZENTRUM, INST BIOTECHNOL 2, D-52425 JULICH, GERMANY
来源：
BIOCATALYSIS | 1994年 / 10卷 / 1-4期
关键词：
D O I：
10.3109/10242429409065216
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The substrate specificity of LeuDH from Bacillus stearothermophilus and of PheDH from Rhodococcus sp. was investigated and found to be complementary. LeuDH from different organisms have remarkably similar substrate specificity. During optimization of the synthesis of L-tert-leucine, two byproducts (N-alpha-pivaloyl-tert-leucine amide (I) and 2,4-di-tert-butyl-5-hydroxy-imidazol (II)) were found and identified which originate from chemical reactions of keto acid and ammonia.
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页码：37 / 47
页数：11
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