THE EFFECT OF TREATMENT WITH INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR ON PSEUDOMONAS-AERUGINOSA LUNG INFECTION IN A GRANULOCYTOPENIC MOUSE MODEL

被引：23

作者：

AMURA, CR ^{[1
]}

FONTAN, PA ^{[1
]}

SANJUAN, N ^{[1
]}

SORDELLI, DO ^{[1
]}

机构：

[1] UNIV BUENOS AIRES, FAC MED, DEPT MICROBIOL, PATOL EXPTL LAB, RA-1121 BUENOS AIRES, DF, ARGENTINA

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1994年 / 73卷 / 02期

关键词：

D O I：

10.1006/clin.1994.1196

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The efficacy of treatment with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF alpha) on Pseudomonas aeruginosa pneumonia was evaluated in a granulocytopenic mouse model. Combined intravenous administration of 2000 U IL-1 beta plus 2000 U TNF alpha significantly diminished mortality from aerosol challenge with P. aeruginosa. Mice treated with IL-1 beta, TNF alpha, or both also exhibited a significant enhancement in pulmonary clearance of P. aeruginosa. Combined cytokine administration induced an increase in the pulmonary content of myeloperoxidase activity. Mature leukocytes were not detected in either circulation or bronchoalveolar lavage fluid from granulocytopenic, cytokine-treated mice. In conclusion, IL-1 beta and TNF alpha treatment exhibited a synergistic protective effect from pulmonary P. aeruginosa challenge in granulocytopenic hosts, probably due to enhancement of nonspecific antibacterial mechanisms. (C) 1994 Academic Press, Inc.

引用

页码：261 / 266

页数：6