NEUROTENSIN STIMULATES PANCREATIC EXOCRINE SECRETION IN RATS

被引：14

作者：

KHALIL, T ^{[1
]}

FUJIMURA, M ^{[1
]}

GREELEY, GH ^{[1
]}

TOWNSEND, CM ^{[1
]}

THOMPSON, JC ^{[1
]}

机构：

[1] UNIV TEXAS, MED BRANCH, DEPT SURG, GALVESTON, TX 77550 USA

来源：

REGULATORY PEPTIDES | 1986年 / 15卷 / 03期

关键词：

D O I：

10.1016/0167-0115(86)90069-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Neurotensin (NT) stimulates pancreatic exocrine secretion in dogs and humans. The purpose of this study was to examine the effect of exogenous neurotensin on pancreatic exocrine secretion in rats. Five Sprague-Dawley male rats were prepared with pancreatic, gastric and duodenal fistulas. Bile was shunted into the duodenum in order to collect pure pancreatic juice. 24 h later, neurotenin (0.05, 0.1, 0.2, 0.3, 1.0 nmol/kg) was infused intravenously in a random fashion. Pancreatic juice was collected every 10 min, and the volume was recorded and protein and bicarbonate were measured. Neurotensin stimulated, in a dose-related manner, the pancreatic secretion of water, protein and bicarbonate. Neurotensin may be involved in the physiologic control of pancreatic secretion in rats.

引用

页码：279 / 284

页数：6

共 23 条

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