LONG-TERM FOLLOW-UP OF A PEDIATRIC CASE OF LIPOPROTEIN GLOMERULOPATHY

被引：24

作者：

KOITABASHI, Y

IKOMA, M

MIYAHIRA, T

FUJITA, R

MIO, H

ISHIDA, M

SHIMIZU, K

SAKAGUCHI, H

机构：

[1] Department of Paediatrics, St. Marianna University School of Medicine, Kawasaki, Kanagawa, 213, 2-16-1 Sugao, Miyamae-ku

[2] First Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, 213, 2-16-1 Sugao, Miyamae-ku

[3] Division of Pathology, Department of Laboratory Medicine, National Children's Hospital, Tokyo

[4] Department of Pathology, Keio University School of Medicine, Tokyo

来源：

PEDIATRIC NEPHROLOGY | 1990年 / 4卷 / 02期

关键词：

Apoprotein E; Glomerular lipoprotein thrombi; Hyper-pre-β-lipoproteinaemia; Lipoprotein glomerulopathy; Mesangiolysis; Nephrotic syndrome;

D O I：

10.1007/BF00858822

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A paediatric case of lipoprotein glomerulopathy, a new kidney disease characterized by glomerular lipoprotein thrombi, is reported. The patient had massive proteinuria from the age of 8 years, when the nephrotic syndrome was first detected. This was resistant to conventional treatment for more than 10 years. During the course of the disease, the hyperlipidaemia characteristic of hyper-pre-β-lipoproteinaemia and elevation of apoprotein E persisted, and renal function gradually deteriorated. The renal histopathological findings from four biopsies were essentially the same, with storage of β-lipoprotein in dilated, balloon-like glomerular capillary lumina. However, the number of glomeruli showing global sclerosis increased and tubulo-interstitial changes progressed in parallel with the gradual clinical deterioration. As in other cases reported in Japan some familial involvement has been noted. © 1990 IPNA.

引用

页码：122 / 128

页数：7

共 26 条

[21]

Linton A.L., Gavras H., Gleadle R.I., Hutchinson J.I.S., Lawson D.H., Lever A.F., Micro-angiopathic haemolytic anaemia and the pathogenesis of malignant hypertension, Lancet, 1, pp. 1277-1282, (1969)

[22]

Segonds A., Louradour N., Suc J.M., Orfila C., Postpartum hemolytic uremic syndrome: a study of three cases with a review of the literature, Clin Nephrol, 12, pp. 229-242, (1979)

[23]

Magil A.B., McFadden D., Raf A., Lupus glomerulonephritis with thrombotic microangiopathy, Hum Pathol, 17, pp. 192-194, (1986)

[24]

Madrazo A., Suzuki Y., Churg J., Radiation nephritis. II. Chronic changes after high doses of radiation, Am J Pathol, 61, pp. 37-56, (1970)

[25]

Price M., Murgo A.J., Keveney J.J., Miller-Hardy D., Kasprisin D.O., Renal failure and hemolytic anemia associated with mytomycin C. A case report, Cancer, 5, pp. 47-50, (1985)

[26]

Hostetter A.L., Tubbs P.R., Ziegler T., Gephardt G.N., McMahan J.T., Schriber M.J., Chronic glomerular microangiopathy complicating metastatic carcinoma, Hum Pathol, 18, pp. 342-348, (1987)

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