DEVELOPMENT OF A METHOD FOR THE DETERMINATION OF ZOPICLONE IN WHOLE-BLOOD

被引：23

作者：

BONIFACE, PJ

MARTIN, IC

NOLAN, SL

TAN, ST

机构：

[1] Institute of Environmental Health and Forensic Sciences, Auckland

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1992年 / 584卷 / 02期

关键词：

D O I：

10.1016/0378-4347(92)80576-C

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Mass spectrometry in both electron-impact and positive chemical ionisation modes has been used to elucidate the structures of the decomposition products of zopiclone after gas chromatography. A high-performance liquid chromatographic method has been developed for the determination of zopiclone in whole blood. After selective extraction (butyl chloride) the extracts are chromatographed on Spherisorb ODS-5 (5 mum) using dibasic ammonium phosphate-acetonitrile (40:60). The zopiclone is measured by ultraviolet detection with a limit of quantitation of 4 ng/ml. This method has been successfully applied to the determination of zopiclone in post-mortem blood. Zopiclone levels found in five post-mortem cases are presented.

引用

页码：199 / 206

页数：8

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