ENTRAPMENT OF BIOMOLECULES INTO HYDROGELS OBTAINED BY RADIATION-INDUCED POLYMERIZATION

被引：11

作者：

CARENZA, M ^{[1
]}

VERONESE, FM ^{[1
]}

机构：

[1] UNIV PADUA,CNR,CTR STUDIO CHIM FARMACO PRODOTTI BIOL ATTIVI,DIPARTIMENTO SCI FARMACEUT,PADUA,ITALY

来源：

JOURNAL OF CONTROLLED RELEASE | 1994年 / 29卷 / 1-2期

关键词：

HYDROGEL; ENZYME IMMOBILIZATION; YEAST CELL IMMOBILIZATION; DRUG RELEASE; PEPTIDE AND PROTEIN RELEASE; RADIATION POLYMERIZATION;

D O I：

10.1016/0168-3659(94)90135-X

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The authors' recent work on the synthesis and characterization of hydrogels and their application for the entrapment of biologically active species is reviewed. The methodology based on low temperature radiation-induced polymerization of acrylic and methacrylic glass-forming monomers is outlined. Immobilization of enzymes. such as penicillin acylase. arginase and glucose oxidase, as well as yeast cells is discussed. Hydrogels as drug delivery systems for the controlled release of both narciclasine, an antimitotic agent, and peptides and proteins with different molecular weights are described.

引用

页码：187 / 193

页数：7

共 34 条

[1]

[Anonymous], 1986, HYDROGELS MED PHARM

[2] RADIATION-INDUCED POLYMERIZATION FOR THE IMMOBILIZATION OF PENICILLIN ACYLASE [J].