RELEASE OF HUMAN SERUM-ALBUMIN FROM POLY(LACTIDE-CO-GLYCOLIDE) MICROSPHERES

被引：208

作者：

HORA, MS ^{[1
]}

RANA, RK ^{[1
]}

NUNBERG, JH ^{[1
]}

TICE, TR ^{[1
]}

GILLEY, RM ^{[1
]}

HUDSON, ME ^{[1
]}

机构：

[1] SO RES INST,BIRMINGHAM,AL 35205

来源：

PHARMACEUTICAL RESEARCH | 1990年 / 7卷 / 11期

关键词：

biodegradable microspheres; human serum albumin; poly(lactide-co-glycolide); protein release; protein stability;

D O I：

10.1023/A:1015948829632

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Human serum albumin (HSA) was encapsulated in a 50:50 copolymer of DL-lactide/glycolide in the form of microspheres. These microspheres were used as a model formulation to study the feasibility of controlling the release of large proteins over a 20- to 30-day period. We show that HSA can be successfully incorporated into microspheres and released intact from these microspheres into various buffer systems at 37°C. A continuous release of the protein could be achieved in physiological buffers at 37°C over a 20- to 30-day period from microspheres with high protein loadings (11.6%). These results demonstrate the potential of poly(DL-lactide-co-glycolide) microspheres for continuous delivery of large proteins. © 1990, Plenum Publishing Corporation. All rights reserved.

引用

页码：1190 / 1194

页数：5

共 22 条

[11] CHEMICAL MODIFICATION OF RECOMBINANT INTERLEUKIN-2 BY POLYETHYLENE-GLYCOL INCREASES ITS POTENCY IN THE MURINE METH-A SARCOMA MODEL [J].