LOCALIZATION OF M5 MUSCARINIC RECEPTOR MESSENGER-RNA IN RAT-BRAIN EXAMINED BY INSITU HYBRIDIZATION HISTOCHEMISTRY

被引：212

作者：

VILARO, MT

PALACIOS, JM

MENGOD, G

机构：

[1] Preclinical Research, Sandoz Pharma Ltd., Basel

来源：

NEUROSCIENCE LETTERS | 1990年 / 114卷 / 02期

关键词：

In situ hybridization; mRNA; Muscarinic receptors; Rat brain; Substantia nigra; Synthetic oligonucleotide;

D O I：

10.1016/0304-3940(90)90064-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The regional distribution of mRNA coding for the m5 muscarinic acetylcholine receptor subtype was investigated in tissue sections of rat brain by in situ hybridization histochemistry. The highest hybridization signal was observed in the hippocampus, but restricted to the ventral subiculum, pyramidal cells of the CA1 and, with lower intensity, of the CA2 subfields. Significant levels of hybridization were also seen in the substantia nigra pars compacta, ventral tegmental area, lateral habenula, ventromedial hypothalamic nucleus and mammillary bodies. An involvement of the m5 muscarinic receptors in the regulation of the dopaminergic nigrostriatal pathway is suggested. © 1990.

引用

页码：154 / 159

页数：6

共 24 条

[1] IDENTIFICATION OF A FAMILY OF MUSCARINIC ACETYLCHOLINE-RECEPTOR GENES [J].