SLIDING CLAMPS OF DNA-POLYMERASES

被引：219

作者：

KURIYAN, J ^{[1
]}

ODONNELL, M ^{[1
]}

机构：

[1] CORNELL UNIV,MED CTR,COLL MED,HOWARD HUGHES MED INST,HEARST RES CTR,DEPT MICROBIOL,NEW YORK,NY 10021

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1993年 / 234卷 / 04期

关键词：

DNA POLYMERASE; SLIDING CLAMPS; PROCESSIVITY FACTOR;

D O I：

10.1006/jmbi.1993.1644

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The determination of the structure of the processivity factor (β subunit) of Escherichia coli DNA polymerase III holoenzyme showed that this protein acts to clamp the polymerase onto DNA by forming a closed circular structure that can encircle duplex DNA (X.-P. Kong, R. Onrust, M. O'Donnell and J. Kuriyan. (1992). Cell, 69, 425-437). In this review we describe the features of the β subunit that allow it to be linked tightly but non-specifically to DNA, and discuss the surprisingly symmetrical architecture of the molecule. The simple repeating pattern of the chain fold allows a connection to be made to the as yet unknown structures of eukaryotic proliferating cell nuclear antigen and the gene 45 protein of bacteriophage T4, which are the processivity factors of the corresponding DNA polymerases. © 1993 Academic Press Limited.

引用

页码：915 / 925

页数：11

共 70 条

[1] CLONING AND SEQUENCE OF THE HUMAN NUCLEAR-PROTEIN CYCLIN - HOMOLOGY WITH DNA-BINDING PROTEINS [J].

ALMENDRAL, JM ;

HUEBSCH, D ;

BLUNDELL, PA ;

MACDONALDBRAVO, H ;

BRAVO, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (06) :1575-1579

[2] THE YEAST ANALOG OF MAMMALIAN CYCLIN PROLIFERATING-CELL NUCLEAR ANTIGEN INTERACTS WITH MAMMALIAN DNA POLYMERASE-DELTA [J].

BAUER, GA ;

BURGERS, PMJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (20) :7506-7510

[3] MOLECULAR-CLONING, STRUCTURE AND EXPRESSION OF THE YEAST PROLIFERATING CELL NUCLEAR ANTIGEN GENE [J].

BAUER, GA ;

BURGERS, PMJ .

NUCLEIC ACIDS RESEARCH, 1990, 18 (02) :261-265

[4] PROGRAMMED RIBOSOMAL FRAMESHIFTING GENERATES THE ESCHERICHIA-COLI DNA POLYMERASE-III GAMMA SUBUNIT FROM WITHIN THE GAMMA-SUBUNIT READING FRAME [J].

BLINKOWA, AL ;

WALKER, JR .

NUCLEIC ACIDS RESEARCH, 1990, 18 (07) :1725-1729

[5] A METHOD TO IDENTIFY PROTEIN SEQUENCES THAT FOLD INTO A KNOWN 3-DIMENSIONAL STRUCTURE [J].

BOWIE, JU ;

LUTHY, R ;

EISENBERG, D .

SCIENCE, 1991, 253 (5016) :164-170

[6] SEARCH FOR DIFFERENTIAL POLYPEPTIDE-SYNTHESIS THROUGHOUT THE CELL-CYCLE OF HELA-CELLS [J].

BRAVO, R ;

CELIS, JE .

JOURNAL OF CELL BIOLOGY, 1980, 84 (03) :795-802

[7] CYCLIN PCNA IS THE AUXILIARY PROTEIN OF DNA POLYMERASE-DELTA [J].

BRAVO, R ;

FRANK, R ;

BLUNDELL, PA ;

MACDONALDBRAVO, H .

NATURE, 1987, 326 (6112) :515-517

[8]

BURGERS PMJ, 1982, J BIOL CHEM, V257, P1468

[9]

BURGERS PMJ, 1991, J BIOL CHEM, V266, P22698

[10] MOLECULAR-CLONING, SEQUENCING, AND OVEREXPRESSION OF THE STRUCTURAL GENE ENCODING THE DELTA-SUBUNIT OF ESCHERICHIA-COLI DNA POLYMERASE-III HOLOENZYME [J].

CARTER, JR ;

FRANDEN, MA ;

AEBERSOLD, R ;

MCHENRY, CS .

JOURNAL OF BACTERIOLOGY, 1992, 174 (21) :7013-7025

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