SLIDING CLAMPS OF DNA-POLYMERASES

被引：219

作者：

KURIYAN, J ^{[1
]}

ODONNELL, M ^{[1
]}

机构：

[1] CORNELL UNIV,MED CTR,COLL MED,HOWARD HUGHES MED INST,HEARST RES CTR,DEPT MICROBIOL,NEW YORK,NY 10021

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1993年 / 234卷 / 04期

关键词：

DNA POLYMERASE; SLIDING CLAMPS; PROCESSIVITY FACTOR;

D O I：

10.1006/jmbi.1993.1644

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The determination of the structure of the processivity factor (β subunit) of Escherichia coli DNA polymerase III holoenzyme showed that this protein acts to clamp the polymerase onto DNA by forming a closed circular structure that can encircle duplex DNA (X.-P. Kong, R. Onrust, M. O'Donnell and J. Kuriyan. (1992). Cell, 69, 425-437). In this review we describe the features of the β subunit that allow it to be linked tightly but non-specifically to DNA, and discuss the surprisingly symmetrical architecture of the molecule. The simple repeating pattern of the chain fold allows a connection to be made to the as yet unknown structures of eukaryotic proliferating cell nuclear antigen and the gene 45 protein of bacteriophage T4, which are the processivity factors of the corresponding DNA polymerases. © 1993 Academic Press Limited.

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页码：915 / 925

页数：11

相关论文

共 70 条

[11] STUDIES OF THE CLONED 37-KDA SUBUNIT OF ACTIVATOR-1 (REPLICATION FACTOR-C) OF HELA-CELLS [J].

CHEN, M ;

PAN, ZQ ;

HURWITZ, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (12) :5211-5215

[12] SEQUENCE AND EXPRESSION IN ESCHERICHIA-COLI OF THE 40-KDA SUBUNIT OF ACTIVATOR-1 (REPLICATION FACTOR-C) OF HELA-CELLS [J].

CHEN, M ;

PAN, ZQ ;

HURWITZ, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (07) :2516-2520

[13]

DONG ZM, 1993, J BIOL CHEM, V268, P11758

[14] DNA POLYMERASE-DELTA - A 2ND EUKARYOTIC DNA REPLICASE [J].

DOWNEY, KM ;

TAN, CK ;

SO, AG .

BIOESSAYS, 1990, 12 (05) :231-236

[15] CYCLIN - A PROTEIN SPECIFIED BY MATERNAL MESSENGER-RNA IN SEA-URCHIN EGGS THAT IS DESTROYED AT EACH CLEAVAGE DIVISION [J].

EVANS, T ;

ROSENTHAL, ET ;

YOUNGBLOM, J ;

DISTEL, D ;

HUNT, T .

CELL, 1983, 33 (02) :389-396

[16]

FAY PJ, 1981, J BIOL CHEM, V256, P976

[17] THE GAMMA-SUBUNIT OF DNA POLYMERASE-III HOLOENZYME OF ESCHERICHIA-COLI IS PRODUCED BY RIBOSOMAL FRAMESHIFTING [J].

FLOWER, AM ;

MCHENRY, CS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (10) :3713-3717

[18] CALCULATING THE ELECTROSTATIC POTENTIAL OF MOLECULES IN SOLUTION - METHOD AND ERROR ASSESSMENT [J].

GILSON, MK ;

SHARP, KA ;

HONIG, BH .

JOURNAL OF COMPUTATIONAL CHEMISTRY, 1988, 9 (04) :327-335

[19] CRYOELECTRON MICROSCOPIC VISUALIZATION OF FUNCTIONAL SUBASSEMBLIES OF THE BACTERIOPHAGE-T4 DNA-REPLICATION COMPLEX [J].

GOGOL, EP ;

YOUNG, MC ;

KUBASEK, WL ;

JARVIS, TC ;

VONHIPPEL, PH .

JOURNAL OF MOLECULAR BIOLOGY, 1992, 224 (02) :395-412

[20] ENHANCEMENT OF BACTERIOPHAGE-T4 LATE TRANSCRIPTION BY COMPONENTS OF THE T4 DNA-REPLICATION APPARATUS [J].

HERENDEEN, DR ;

KASSAVETIS, GA ;

BARRY, J ;

ALBERTS, BM ;

GEIDUSCHEK, EP .

SCIENCE, 1989, 245 (4921) :952-958

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