SYNTHESIS AND BIOLOGICAL EVALUATION OF 1-SUBSTITUTED-7-(1-HYDROXYETHYL) CARBACEPHEMS - A CLASS OF HYBRID BICYCLIC BETA-LACTAMS

被引：11

作者：

HANESSIAN, S

ROZEMA, MJ

机构：

[1] Department of Chemistry, Montréal, Que. H3C 3J7, Universite Montreal P.O. Box 6128, Succ. Centre-ville

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 19期

关键词：

D O I：

10.1016/0960-894X(94)85025-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The total synthesis of prototypical carbacephem models that incorporate features of carbapenems and cephems and their preliminary biological evaluation are described.

引用

页码：2279 / 2284

页数：6

共 47 条

[1] STRUCTURE AND ABSOLUTE-CONFIGURATION OF THIENAMYCIN [J].

ALBERSSCHONBERG, G ;

ARISON, BH ;

HENSENS, OD ;

HIRSHFIELD, J ;

HOOGSTEEN, K ;

KACZKA, EA ;

RHODES, RE ;

KAHAN, JS ;

KAHAN, FM ;

RATCLIFFE, RW ;

WALTON, E ;

RUSWINKLE, LJ ;

MORIN, RB ;

CHRISTENSEN, BG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1978, 100 (20) :6491-6499

[2] SYNTHESIS OF DEOXYHALOGENO SUGARS - REACTION OF HALIDE-IONS WITH 1,2,3,4-TETRA-O-ACETYL-6-O-[(TRIFLUOROMETHYL)SULFONYL]-BETA-D-GLUCOPYRANOSE [J].

AMBROSE, MG ;

BINKLEY, RW .

JOURNAL OF ORGANIC CHEMISTRY, 1983, 48 (05) :674-677

[3] SYNTHESIS OF A DELTA-1,6-1-CARBACEPHEM-4-CARBOXYLIC ACID-DERIVATIVE AS PROTOTYPE FOR A NEW FAMILY OF FUSED BICYCLIC BETA-LACTAMS [J].

BACHI, MD ;

BARNER, N .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (11) :2439-2442

[4] SYNTHESIS OF DEOXYHALOGENO SUGARS - DISPLACEMENT OF THE (TRIFLUOROMETHANESULFONYL)OXY (TRIFLYL) GROUP BY HALIDE ION [J].

BINKLEY, RW ;

AMBROSE, MG ;

HEHEMANN, DG .

JOURNAL OF ORGANIC CHEMISTRY, 1980, 45 (22) :4387-4391

[5] CEPHALOSPORANIC ACIDS .2. DISPLACEMENT OF ACETOXY-GROUP BY NUCLEOPHILES [J].

COCKER, JD ;

COWLEY, BR ;

COX, JSG ;

EARDLEY, S ;

GREGORY, GI ;

LAZENBY, JK ;

LONG, AG ;

SLY, JCP ;

SOMERFIE.GA .

JOURNAL OF THE CHEMICAL SOCIETY, 1965, (SEP) :5015-&

[6]

COOPER RDG, 1992, CHEM BETA LACTAMS, P272

[7]

DURCKHEIMER W, 1985, ANGEW CHEM INT EDIT, V24, P150

[8]

DURCKHEIMER W, 1984, RECENT ADV CHEM BETA

[9]

GEORG GI, 1993, ORGANIC CHEM BETA LA

[10]

GEORGOPAPADAKOU NH, 1983, ANNU REP MED CHEM, V18, P119

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