ENHANCEMENT OF IGG PRODUCTION ELICITED IN MICE BY TREATMENT WITH ANTI-CD8 ANTIBODY

被引：15

作者：

COUTELIER, JP ^{[1
]}

机构：

[1] INT INST CELLULAR & MOLEC PATHOL,B-1200 BRUSSELS,BELGIUM

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1991年 / 21卷 / 10期

关键词：

D O I：

10.1002/eji.1830211046

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Injection of an anti-CD8 monoclonal antibody into mice was followed by an increase in the production of immunoglobulins of the IgG1, IgG2a and IgG2b, but neither the IgG3 nor the IgM isotypes. A maximal effect was observed 6 days after administration of 100-mu-g antibody. However, no modification of spleen cell proliferation was elicited by the anti-CD8 treatment. Virally induced IgG2a and IgG2b secretion remained unchanged in mice infected with lactate dehydrogenase-elevating virus that received a concomitant injection of anti-CD8 antibody, whereas an enhancement of IgG1 was observed. Simultaneous treatment with an anti-CD4 antibody abrogated the immunoglobulin secretion triggered by anti-CD8. These results suggest that immunoglobulin production in unmanipulated mice is controlled by CD8+ lymphocytes.

引用

页码：2617 / 2620

页数：4

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