PROMOTER TARGETING BY ADENOVIRUS-E1A THROUGH INTERACTION WITH DIFFERENT CELLULAR DNA-BINDING DOMAINS

被引：237

作者：

LIU, F ^{[1
]}

GREEN, MR ^{[1
]}

机构：

[1] UNIV MASSACHUSETTS, MED CTR, PROGRAM MOLEC MED, WORCESTER, MA 01605 USA

来源：

NATURE | 1994年 / 368卷 / 6471期

关键词：

D O I：

10.1038/368520a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A puzzling property of the transcriptional activators encoded by several animal viruses is their ability to function promiscuously. The adenovirus E1a protein, for example, stimulates transcription of adenoviral genes as well as a wide variety of other viral and cellular genes. We show that E1a can interact with several classes of cellular DNA-binding domains and thereby be recruited to diverse promoters. Our results explain how a single protein can regulate transcription of multiple genes that lack a common promoter element.

引用

页码：520 / 525

页数：6

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