VARIATIONS IN SOLID-PHASE EXTRACTION OF BASIC DRUGS USING BONDED SILICA .3. PHASE-TO-PHASE VARIATIONS

被引：8

作者：

MARKO, V

RADOVA, K

机构：

[1] Institute of Experimental Pharmacology, Slovak Academy of Sciences, CS-84216, Bratislava, CSFR

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1991年 / 14卷 / 09期

关键词：

D O I：

10.1080/01483919108049644

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Phase-to-phase variations of solid-phase extraction of basic drugs were studied using elution profiles obtained after elution of three model drugs from C18-, C8- and CN-silica. Variations were observed in the extraction of model drugs (in total recovery as well as in the course of elution profiles) and of endogenous compounds from serum. Various types of interactions depending on hydrophobic properties of the drugs and of the silica-modifiers were found to affect the process.. Hydrophobic interactions facilitated not only adsorption but also elution of hydrophobic drugs from hydrophobic sorbents.

引用

页码：1671 / 1682

页数：12

共 10 条

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