MAPPING OF THE HUMAN ZN-ALPHA(2)-GLYCOPROTEIN GENE (AZGP1) TO CHROMOSOME 7Q22 BY IN-SITU HYBRIDIZATION

被引：27

作者：

PENDAS, AM

MATILLA, T

URIA, JA

FREIJE, JP

FUEYO, A

ESTIVILL, X

LOPEZOTIN, C

机构：

[1] UNIV OVIEDO, FAC MED, DEPT BIOL FUNC, E-33006 OVIEDO, SPAIN

[2] HOSP DURAN & REYNALS, IRO, DEPT MOLEC GENET, BARCELONA, SPAIN

来源：

CYTOGENETICS AND CELL GENETICS | 1994年 / 66卷 / 04期

关键词：

D O I：

10.1159/000133708

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The gene coding for Zn-alpha(2)-glycoprotein (AZGP1), a human protein with a high degree of similarity to class I major histocompatibility complex (MHC) antigens, was mapped by fluorescent in situ hybridization to chromosome 7q22, a common breakpoint in myelodysplastic syndromes. Since classical MHC genes map on chromosome 6, this assignment indicates that besides duplication of the putative common ancestor gene, transposition events to different chromosomes have also been involved in the evolutionary diversification of this gene family.

引用

页码：263 / 266

页数：4

共 24 条

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