THE CHEMICAL SYNTHESIS OF PEPTIDOMIMETIC LIBRARIES

被引：33

作者：

ZUCKERMANN, RN

机构：

[1] RN Zuckerman, Chiron Corporation, Emeryville, CA 94608

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1993年 / 3卷 / 04期

关键词：

D O I：

10.1016/0959-440X(93)90086-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Molecular diversity as a source of potential drug candidates has been an area of tremendous growth during the past year. The field has been dominated by investigations featuring diverse peptide libraries, generated by both chemical and biological methods. Yet the many undesirable properties of peptides as drugs, such as poor oral availability and low in vivo stability, have prompted chemists to develop methods for the efficient synthesis of conformationally constrained peptide, biopolymer and non-polymeric compound collections.

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页码：580 / 584

页数：5

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