SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF FR21818, A NEW, POTENT 1-BETA-METHYLCARBAPENEM

被引:12
作者
AZAMI, H
BARRETT, D
TANAKA, A
SASAKI, H
MATSUDA, K
CHIBA, T
MATSUMOTO, Y
MATSUMOTO, S
MORINAGA, C
ISHIGURO, K
TAWARA, S
SAKANE, K
TAKASUGI, H
机构
[1] New Drug Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Yodogawa-ku, Osaka, 532
关键词
D O I
10.1016/0960-894X(95)00380-C
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The synthesis, in vitro antibacterial activity, and stability to renal dehydropeptidase I of FR21818, a new 1 beta-methyl carbapenem containing a novel pyrazoliomethyl pyrrolidine side chain at C-2 is described.
引用
收藏
页码:2199 / 2202
页数:4
相关论文
共 19 条
[1]   THE METALATION OF 1-PHENYLPYRAZOLE AND 1-METHYLPYRAZOLE WITH NORMAL-BUTYLLITHIUM [J].
ALLEY, PW ;
SHIRLEY, DA .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1958, 80 (23) :6271-6274
[2]   NEW METHOD FOR DEOXYGENATION OF SECONDARY ALCOHOLS [J].
BARTON, DHR ;
MCCOMBIE, SW .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1975, (16) :1574-1585
[3]   IMIPENEM CILASTATIN - A REAPPRAISAL OF ITS ANTIBACTERIAL ACTIVITY, PHARMACOKINETIC PROPERTIES AND THERAPEUTIC EFFICACY [J].
BUCKLEY, MM ;
BROGDEN, RN ;
BARRADELL, LB ;
GOA, KL .
DRUGS, 1992, 44 (03) :408-444
[5]   RENAL DEHYDROPEPTIDASE-I STABILITY OF LJC 10,627, A NEW CARBAPENEM ANTIBIOTIC [J].
HIKIDA, M ;
KAWASHIMA, K ;
NISHIKI, K ;
FURUKAWA, Y ;
NISHIZAWA, K ;
SAITO, I ;
KUWAO, S .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (02) :481-483
[6]   HOMOGENEOUS, PALLADIUM(0)-CATALYZED EXCHANGE DEPROTECTION OF ALLYLIC ESTERS, CARBONATES, AND CARBAMATES [J].
JEFFREY, PD ;
MCCOMBIE, SW .
JOURNAL OF ORGANIC CHEMISTRY, 1982, 47 (03) :587-590
[7]   ENANTIOSPECIFIC SYNTHESIS OF FUNCTIONALIZED INDOLIZIDINES - SYNTHESIS OF (8S,8AR)-6,7-DEHYDRO-8-HYDROXYINDOLIZIDINE [J].
KOSKINEN, AMP ;
PAUL, JM .
TETRAHEDRON LETTERS, 1992, 33 (45) :6853-6856
[8]   A CONVENIENT PROCEDURE FOR THE MONOSILYLATION OF SYMMETRICAL 1,N-DIOLS [J].
MCDOUGAL, PG ;
RICO, JG ;
OH, YI ;
CONDON, BD .
JOURNAL OF ORGANIC CHEMISTRY, 1986, 51 (17) :3388-3390
[9]   BETA-LACTAMS .3. ASYMMETRIC TOTAL SYNTHESIS OF NEW NONNATURAL 1-BETA-METHYLCARBAPENEMS EXHIBITING STRONG ANTIMICROBIAL ACTIVITIES AND STABILITY AGAINST HUMAN RENAL DEHYDROPEPTIDASE-I [J].
NAGAO, Y ;
NAGASE, Y ;
KUMAGAI, T ;
MATSUNAGA, H ;
ABE, T ;
SHIMADA, O ;
HAYASHI, T ;
INOUE, Y .
JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (15) :4243-4249
[10]   IN-VITRO ACTIVITY OF A NEW CARBAPENEM ANTIBIOTIC, BO-2727, WITH POTENT ANTIPSEUDOMONAL ACTIVITY [J].
NAKAGAWA, S ;
HASHIZUME, T ;
MATSUDA, K ;
SANADA, M ;
OKAMOTO, O ;
FUKATSU, H ;
TANAKA, N .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (12) :2756-2759