RADIATION RESPONSE OF HELA CELLS EXPOSED AT VERY LOW TEMPERATURES

被引：7

作者：

HALL, DR

LEWIS, JD

TOWN, CD

FISH, PJ

LINDOP, PJ

机构：

[1] Department of Radiobiology, Medical College of St. Bartholomew's Hospital, London

[2] Division of Applied Physics and Electrical Sciences, Engineering Design Center, Case Western Reserve University

[3] Department of Radiology, Stanford Medical Center, Palo Alto

[4] Physics Department, King's College Hospital, London, S.E.5, Denmark Hill

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY AND RELATED STUDIES IN PHYSICS CHEMISTRY AND MEDICINE | 1969年 / 16卷 / 01期

关键词：

D O I：

10.1080/09553006914551031

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

HeLa-S-3 cells have been irradiated with 14 MeV electrons in single doses, at temperatures from 310°K down to 77°K. The best plating efficiency resulted from cooling the cells at 1°K/min in the presence of 15 per cent glycerol, and then plunging into the refrigerant, and rapid thawing post-irradiation. Over the temperature range studied the D0 of the cell survival curve increased three-fold at the change of state, i.e. the freezing point, then increased at about 0·8 rad per °K. The extrapolation number was increased three-fold at 77°K, but hypoxia did not further modify the D0 or extrapolation number at this temperature. © 1969 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：43 / &

共 9 条

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