A NOVEL CARBAPENEM ANTIBIOTIC, SM-7338 STRUCTURE-ACTIVITY-RELATIONSHIPS

被引:195
作者
SUNAGAWA, M
MATSUMURA, H
INOUE, T
FUKASAWA, M
KATO, M
机构
[1] Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd., Osaka 554
关键词
D O I
10.7164/antibiotics.43.519
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A series of new carbapenem compounds, which have a pyrrolidin-3′-ylthio group substituted with various aminocarbonyl group at C-5′ position as C-2 side chain, have been prepared. The antibacterial activity and the stability to renal dehydropeptidase-I of these compounds were investigated, and the structure-activity relationships were discussed. In this series, SM-7338; (1R,5S,6S)-2-[(3S,5S)-5-dimethylaminocarbonylpyrrolidin-3-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid (5a) was the most interesting compound. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
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页码:519 / 532
页数:14
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