BLOOD-VISCOSITY IN HORSES WITH COLIC

被引:11
作者
ANDREWS, FM
HAMLIN, RL
STALNAKER, PS
机构
[1] Department of Rural Practice, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee
[2] Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Ohio State University, Columbus, Ohio
关键词
D O I
10.1111/j.1939-1676.1990.tb00895.x
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Whole blood viscosity (WBV) was measured on six healthy horses and ten horses presented for colic surgery. A Wells‐Brookfield cone‐and‐plate microviscometer* at 6 rpm was used to determine WBV and WBV was adjusted for packed cell volume (PCV). The ten colic horses were divided into two groups: five horses that died or were euthanatized (group 1) and five horses that were discharged after surgery and medical therapy (group 2). The mean WBV for each group was compared using analysis of variance followed by Duncan multiple‐range tests. Mean WBV of group 2 (5.81 ± 1.48 centipoise [cp]) and normal horses (7.1 ± 2.3 cp) was significantly (P < 0.01) lower than group 1 (17.15 ± 5.71 cp). This preliminary trial shows that horses that died or were euthanatized had a significantly higher WBV than horses surviving. Since viscosity was adjusted for PCV, the differences may represent changes in other factors such as fibrinogen, rouleaux formation, red blood cell deformability, PaO2, or intracellular calcium ion concentration. Thus, increases in WBV in horses with colic may indicate severely compromised regional perfusion that may lead to significant tissue damage. In this preliminary study, it appears that WBV may be a prognostic aid in horses with colic. (Journal of Veterinary Internal Medicine 1990; 4:183–186) Copyright © 1990, Wiley Blackwell. All rights reserved
引用
收藏
页码:183 / 186
页数:4
相关论文
共 28 条
[11]  
Dintenfass L., Blood viscosity, internal fluidity of the red cell, dynamic coagulation and the critical capillary radius as factors in the physiology and pathology of the circulation and micro‐circulation, Med J Aust, 1, pp. 688-696, (1968)
[12]  
Fogarty TJ, Fletcher WS, Genesis of non‐occlusive mesenteric ischemia, Am J Surg, 111, pp. 130-135, (1966)
[13]  
Gatti RA, Muster AJ, Cole RB, Et al., Neonatal polycythemia with transient cyanosis and cardiorespiratory abnormalities, J Pediatr, 69, pp. 1063-1072, (1966)
[14]  
Fouron JC, Hebert F., The circulatory effect of hematocrit varia‐tion in normovolemic newborn lambs, J Pediatr, 82, pp. 995-1003, (1973)
[15]  
Replogle RL, Merrill EW, Experimental polycythemia and hemo‐dilution: Physiologic and Theological effects, J Thorac Cardio-vasc Surg, 60, pp. 582-588, (1970)
[16]  
Murray J., Gold P., Johnson BL, The circulatory effects of he‐matocrit variations in normovolemic and hypervolemic dogs, J Clin Invest, 42, pp. 1150-1159, (1963)
[17]  
Merrill EW, Cheng CS, Pelletier GA., Yield stress of normal human blood as a function of endogenous fibrinogen, J Appl Physiol, 26, pp. 1-3, (1969)
[18]  
Ferguson EW, Bernier LL, Shaughness GP, Et al., Fibrinolytic ac‐tivity without fibrinolysis during long distance racing in horses, J Appl Physiol, 50, pp. 245-249, (1981)
[19]  
Haynes RH, Physical basis of the dependence of blood viscosity on tube radius, Am J Physiol, 198, pp. 1193-1200, (1960)
[20]  
Boucher JH, Ferguson EW, Wilhelsmen CL, Et al., Erythrocyte alterations during endurance exercise in horses, J Appl Physiol, 51, pp. 131-134, (1981)