学术探索
学术期刊
新闻热点
数据分析
智能评审

T-CELLS AND EOSINOPHILS IN THE PATHOGENESIS OF ASTHMA

被引：537
作者：
CORRIGAN, CJ
KAY, AB
机构：
[1] C.J. Corrigan and A.B. Kay are, the Dept of Allergy and Clinical Immunology, National Heart and Lung Institute, London, SW3 6LY, Dovehouse Street
来源：
IMMUNOLOGY TODAY | 1992年 / 13卷 / 12期
关键词：
D O I：
10.1016/0167-5699(92)90026-4
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Persistent asthma is characterized by chronic inflammation of the bronchial mucosa, where T cells and eosinophils are prominent. This article summarizes the evidence that asthmatic bronchial inflammation is initiated and propagated by cytokines secreted by activated T cells and other cells, and describes how the release of specific cytokines could result in local preferential accumulation and activation of eosinophils.
引用
收藏
页码：501 / 507
页数：7
相关论文
共 63 条
  • [11] INTERLEUKIN-3-DEPENDENT AND INTERLEUKIN-3-INDEPENDENT MAST-CELLS STIMULATED WITH IGE AND ANTIGEN EXPRESS MULTIPLE CYTOKINES
    BURD, PR
    ROGERS, HW
    GORDON, JR
    MARTIN, CA
    JAYARAMAN, S
    WILSON, SD
    DVORAK, AM
    GALLI, SJ
    DORF, ME
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (01) : 245 - 257
  • [12] ASSOCIATION OF ASTHMA WITH SERUM IGE LEVELS AND SKIN-TEST REACTIVITY TO ALLERGENS
    BURROWS, B
    MARTINEZ, FD
    HALONEN, M
    BARBEE, RA
    CLINE, MG
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (05) : 271 - 277
  • [13] A SPECIFIC LTD4 LTE4-RECEPTOR ANTAGONIST IMPROVES PULMONARY-FUNCTION IN PATIENTS WITH MILD, CHRONIC ASTHMA
    CLOUD, ML
    ENAS, GC
    KEMP, J
    PLATTSMILLS, T
    ALTMAN, LC
    TOWNLEY, R
    TINKELMAN, D
    KING, T
    MIDDLETON, E
    SHEFFER, AL
    MCFADDEN, ER
    FARLOW, DS
    [J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1989, 140 (05): : 1336 - 1339
  • [14] CLUTTERBUCK EJ, 1989, BLOOD, V73, P1504
  • [15] GLUCOCORTICOID RESISTANCE IN CHRONIC ASTHMA - GLUCOCORTICOID PHARMACOKINETICS, GLUCOCORTICOID RECEPTOR CHARACTERISTICS, AND INHIBITION OF PERIPHERAL-BLOOD T-CELL PROLIFERATION BY GLUCOCORTICOIDS INVITRO
    CORRIGAN, CJ
    BROWN, PH
    BARNES, NC
    SZEFLER, SJ
    TSAI, JJ
    FREW, AJ
    KAY, AB
    [J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991, 144 (05): : 1016 - 1025
  • [16] CD4 LYMPHOCYTE-T ACTIVATION IN ACUTE SEVERE ASTHMA - RELATIONSHIP TO DISEASE SEVERITY AND ATOPIC STATUS
    CORRIGAN, CJ
    KAY, AB
    [J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 141 (04): : 970 - 977
  • [17] CORRIGAN CJ, 1988, LANCET, V1, P1129
  • [18] GLUCOCORTICOID RESISTANCE IN CHRONIC ASTHMA - PERIPHERAL-BLOOD LYMPHOCYTE-T ACTIVATION AND COMPARISON OF THE LYMPHOCYTE-T INHIBITORY EFFECTS OF GLUCOCORTICOIDS AND CYCLOSPORINE-A
    CORRIGAN, CJ
    BROWN, PH
    BARNES, NC
    TSAI, JJ
    FREW, AJ
    KAY, AB
    [J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991, 144 (05): : 1026 - 1032
  • [19] CROMWELL O, 1990, J IMMUNOL, V145, P3862
  • [20] CROMWELL O, IN PRESS IMMUNOLOGY
1234567