CYCLOTHIAZIDE REVERSES AMPA RECEPTOR ANTAGONISM OF THE 2,3-BENZODIAZEPINE, GYKI-53655

被引：69

作者：

PALMER, AJ

LODGE, D

机构：

[1] LILLY RES CTR LTD,ERL WOOD MANOR,WINDLESHAM GU20 6PH,SURREY,ENGLAND

[2] UNIV LONDON ROYAL VET COLL,DEPT VET BASIC SCI,LONDON NW1 0TU,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1993年 / 244卷 / 02期

关键词：

GLUTAMATE RECEPTORS; CYCLOTHIAZIDE; AMPA (ALPHA-AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONATE); GYKI-53655;

D O I：

10.1016/0922-4106(93)90027-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

On rat cortical slices, cyclothiazide, 1-100 muM, (ED50 = 7.1 +/- 1.1 muM) enhanced the depolarizing action of alpha-amino-3-hydroxY-5-methylisoxazole-4-propionate (AMPA) but not that of N-methyl-D-aspartate (NMDA). Cyclothiazide 10 muM also reversed the action of a 2,3-benzodiazepine, GYKI 53655, which is a non-competitive AMPA receptor antagonist, but not that of the quinoxalinedione, NBQX, which is a competitive AMPA receptor antagonist.

引用

页码：193 / 194

页数：2

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