INCORPORATION OF C-14 IN THE BIOSYNTHESIS OF THE MACROLIDE ANTIBIOTIC, LL-F28249-ALPHA

被引：7

作者：

AHMED, ZH

FIALA, RR

BULLOCK, MW

机构：

[1] Agricultural Research Division, American Cyanamid Company, New Jersey, 08543-0400, Princeton

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 04期

关键词：

D O I：

10.7164/antibiotics.46.614

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A total of 76 mCi of C-14 LL-F28249-alpha, nemadectin (1), having a specific activity of 35.2 muCi/mg was isolated from a fermentation using a mixture of approximately 600 mCi of C-14 carboxyl labeled acetate, propionate and isobutyrate. Nemadectin was used to synthesize carbon-14 labeled moxidectin which is being developed as a highly efficient ectoparasitic anthelminth. The labeled positions were determined by C-13 NMR analysis of C-13 nemadectin which was obtained by similar incorporation of C-13 carboxyl labeled acetate, propionate and isobutyrate.

引用

页码：614 / 622

页数：9

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