INSULIN-LIKE GROWTH-FACTOR GENE-EXPRESSION IN HUMAN FRACTURE CALLUS

被引：109

作者：

ANDREW, JG ^{[1
]}

HOYLAND, J ^{[1
]}

FREEMONT, AJ ^{[1
]}

MARSH, D ^{[1
]}

机构：

[1] UNIV MANCHESTER,SCH MED,DEPT PATHOL SCI,MANCHESTER M13 9PT,LANCS,ENGLAND

来源：

CALCIFIED TISSUE INTERNATIONAL | 1993年 / 53卷 / 02期

关键词：

INSULIN-LIKE GROWTH FACTOR; FRACTURE; IN-SITU HYBRIDIZATION;

D O I：

10.1007/BF01321886

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of insulinlike growth factors on bone and cartilage-derived cells in culture have been extensively investigated, but there is little information on their role in vivo in bone, especially in fracture healing. This study investigated insulinlike growth factor (IGF) I and II mRNA expression in normally healing human fractures by in situ hybridization. Endothelial and mesenchymal cells at the granulation tissue stage expressed IGF-II mRNA. At the stage of bone and cartilage formation, osteoblasts and non-hypertrophic chondrocytes expressed mRNA for both IGF-I and II. Some osteoclasts were positive for IGF-II mRNA at the stage of bone remodeling. The greater time span of IGF-II expression relative to IGF-I reflects the predominance of IGF-II in human bone matrix. Taken together with the known effects of IGFs on bone and cartilage cells in vitro, these findings support a role for IGFs in local cellular regulation in human fracture healing.

引用

页码：97 / 102

页数：6

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