Antigen processing and intracellular traffic of antigens and MHC molecules

被引：50

作者：

Harding, Clifford V. ^{[1
]}

Geuze, Hans J. ^{[2
]}

机构：

[1] Case Western Reserve Univ, Inst Pathol, Cleveland, OH 44106 USA

[2] Univ Utrecht, Dept Cell Biol, NL-3584 CX Utrecht, Netherlands

来源：

CURRENT OPINION IN CELL BIOLOGY | 1993年 / 5卷 / 04期

关键词：

D O I：

10.1016/0955-0674(93)90128-D

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Antigen processing leads to binding of antigenic peptides to major histocompatibility complex (MHC) molecules, and these peptide MHC complexes are recognized by T cells. The class I and class II MHC antigen processing pathways employ different mechanisms and patterns of intracellular transport that allow the two classes to bind and present peptides from different subcellular compartments, determining the source and nature of peptides to be presented.

引用

页码：596 / 605

页数：10

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