OPTIMIZATION OF AN INDUSTRIAL MICROALGAE FERMENTATION

被引:19
作者
HILALY, AK [1 ]
KARIM, MN [1 ]
GUYRE, D [1 ]
机构
[1] COORS BIOTECH PROD CO,FT COLLINS,CO 80525
关键词
SPONGIOCOCCUM EXETRICICUM; FED-BATCH FERMENTATION; FERMENTATION; MICROALGAE FERMENTATION; FEEDBACK CONTROL;
D O I
10.1002/bit.260430408
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Optimization of cellular productivity of an industrial microalgae fermentation was investigated. The fermentation was carried out at Coors Biotech Products Company, Fort Collins, Colorado. A mathematical model was developed based on the data collected from pilot plant test runs at different operating conditions. Pontryagin's maximum principle was used for determining the optimal feed policy. A feedback control algorithm was also studied for maximizing the cellular productivity. During continuous operation, the optimum dilution rate was determined by an adaptive optimization scheme based on the steepest descent technique and a recursive least squares estimation of model parameters. A direct search algorithm was also applied to determine the optimum feed rate. Comparison of the theoretical results of the different optimization schemes revealed that the direct search algorithm was preferable because of its simplicity. The experimental results of real time application of the feedback algorithm agreed fairly well with those of the theoretical analyses. (C) 1994 John Wiley and Sons, Inc.
引用
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页码:314 / 320
页数:7
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