PREPARATION OF NOVEL LIPOPHILIC GABA ANALOGS CONTAINING CYCLOPROPANE RINGS VIA CYCLOPROPANATION OF N-SILYLATED UNSATURATED AMINES

被引：21

作者：

PAULINI, K

REISSIG, HU

机构：

[1] TECH UNIV DRESDEN,INST ORGAN CHEM,D-01062 DRESDEN,GERMANY

[2] TH DARMSTADT,INST ORGAN CHEM,DARMSTADT,GERMANY

来源：

JOURNAL FUR PRAKTISCHE CHEMIE-CHEMIKER-ZEITUNG | 1995年 / 337卷 / 01期

关键词：

D O I：

10.1002/prac.19953370112

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Novel lipophilic gamma-amino acids 8 and 9 analogous to GABA containing cyclopropane rings are synthesized by Rh(II)-catalyzed reaction of diazo compounds 2 and 3 with N,N-bis(trimethylsilyl)allylamine (1) and subsequent hydrolysis. In addition, routes are described leading to the vinylogous GABA analogue 15 and to the unusual tricyclic gamma-amino acid 20.

引用

页码：55 / 59

页数：5

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