Biological properties of extracellular vesicles and their physiological functions

被引：3971

作者：

Yanez-Mo, Maria ^{[1
,2
]}

Siljander, Pia R. -M. ^{[3
,4
]}

Andreu, Zoraida ^{[1
,2
]}

Zavec, Apolonija Bedina ^{[5
]}

Borras, Francesc E. ^{[6
,7
]}

Buzas, Edit I. ^{[8
]}

Buzas, Krisztina ^{[9
,10
]}

Casal, Enriqueta ^{[11
]}

Cappello, Francesco ^{[12
,13
]}

Carvalho, Joana ^{[14
,15
]}

Colas, Eva ^{[16
,17
]}

Cordeiro-da Silva, Anabela ^{[14
,18
,19
]}

Fais, Stefano ^{[20
]}

Falcon-Perez, Juan M. ^{[11
,21
]}

Ghobrial, Irene M. ^{[22
]}

Giebel, Bernd ^{[23
]}

Gimona, Mario ^{[24
,25
]}

Graner, Michael ^{[26
]}

Gursel, Ihsan ^{[27
]}

Gursel, Mayda ^{[28
]}

Heegaard, Niels H. H. ^{[29
,30
]}

Hendrix, An ^{[31
]}

Kierulf, Peter ^{[32
]}

Kokubun, Katsutoshi ^{[22
]}

Kosanovic, Maja ^{[33
]}

Kralj-Iglic, Veronika ^{[34
]}

Kraemer-Albers, Eva-Maria ^{[35
]}

Laitinen, Saara ^{[36
]}

Lasser, Cecilia ^{[37
]}

Lener, Thomas ^{[24
,25
]}

Ligeti, Erzsebet ^{[38
]}

Line, Aija ^{[39
]}

Lipps, Georg ^{[40
]}

Llorente, Alicia ^{[41
]}

Lotvall, Jan ^{[37
]}

Mancek-Keber, Mateja ^{[42
,43
]}

Marcilla, Antonio ^{[44
]}

Mittelbrunn, Maria ^{[45
]}

Nazarenko, Irina ^{[46
,47
]}

Nolte-t' Hoen, Esther N. M. ^{[48
]}

Nyman, Tuula A. ^{[49
]}

O'Driscoll, Lorraine ^{[50
,51
]}

Olivan, Mireia ^{[16
,17
]}

Oliveira, Carla ^{[14
,15
,52
]}

Pallinger, Eva ^{[8
]}

del Portillo, Hernando A. ^{[53
,54
]}

Reventos, Jaume ^{[16
,17
,55
,56
]}

Rigau, Marina ^{[16
,17
]}

Rohde, Eva ^{[24
,25
]}

Sammar, Marei ^{[57
]}

机构：

[1] Hosp Sta Cristina, Inst Invest Sanitarias Princesa IIS IP, Unidad Invest, Madrid, Spain

[2] UAM, Dept Biol Mol, ES-28009 Madrid, Spain

[3] Univ Helsinki, Dept Biosci, Div Biochem & Biotechnol, Extracellular Vesicle Res, FI-00014 Helsinki, Finland

[4] Univ Helsinki, Fac Pharm, Div Pharmaceut Biosci, FI-00014 Helsinki, Finland

[5] Natl Inst Chem, Lab Mol Biol & Nanobiotechnol, Ljubljana, Slovenia

[6] Germans Trias & Pujol Res Inst, IVECAT Grp, Badalona, Spain

[7] Germans Trias & Pujol Univ Hosp, Serv Nephrol, Badalona, Spain

[8] Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1085 Budapest, Hungary

[9] Hungarian Acad Sci, Biol Res Ctr, H-6701 Szeged, Hungary

[10] Univ Szeged, Fac Dent, Szeged, Hungary

[11] CIBERehd, CIC BioGUNE, Metabol Unit, Derio, Spain

[12] Univ Palermo, Human Anat Sect, Dept Expt Biomed & Clin Neurosci, Palermo, Italy

[13] Euromediterranean Inst Sci & Technol, Palermo, Italy

[14] Univ Porto, Inst Invest & Inovacao Saude, P-4100 Oporto, Portugal

[15] Univ Porto IPATIMUP, Inst Mol Pathol & Immunol, Express Regulat Canc, Oporto, Portugal

[16] Vall Hebron Inst Res, Res Unit Biomed & Translat Oncol, Barcelona, Spain

[17] Autonomous Univ Barcelona, Barcelona, Spain

[18] Univ Porto, IBMC, P-4100 Oporto, Portugal

[19] Univ Porto, Fac Pharm, Dept Biol Sci, P-4100 Oporto, Portugal

[20] Natl Inst Hlth ISS, Dept Therapeut Res & Med Evaluat, Antitumour Drugs Sect, Rome, Italy

[21] Basque Fdn Sci, Ikerbasque, Bilbao, Spain

[22] Dana Farber Canc Inst, Boston, MA 02115 USA

[23] Univ Duisburg Essen, Univ Hosp Essen, Inst Transfus Med, Essen, Germany

[24] PMU, Spinal Cord Injury & Tissue Regenerat Ctr Salzbur, Salzburg, Austria

[25] Salzburger Landeskliniken GesmbH SALK, Univ Klinikum, Dept Blood Grp Serol & Transfus Med, Salzburg, Austria

[26] Univ Colorado, Dept Neurosurg, Denver, CO 80202 USA

[27] Bilkent Univ, Therapeut Oligonucleotide Res Lab, Dept Mol Biol & Genet, Thorlab, Ankara, Turkey

[28] Middle E Tech Univ, Dept Biol Sci, TR-06531 Ankara, Turkey

[29] Univ Southern Denmark, Odense Univ Hosp, Dept Clin Biochem & Pharmacol, Odense, Denmark

[30] Statens Serum Inst, Dept Clin Biochem Immunol & Genet, Analyt Prot Chem, DK-2300 Copenhagen, Denmark

[31] Ghent Univ Hosp, Dept Radiat Oncol & Expt Canc Res, Lab Expt Canc Res, Ghent, Belgium

[32] Oslo Univ Hosp, Dept Med Biochem, Bood Cell Res Grp, Oslo, Norway

[33] Univ Belgrade, INEP, Inst Applicat Nucl Energy, Dept Immunochem & Glycobiol, Belgrade, Serbia

[34] Univ Ljubljana, Fac Hlth Sci, Lab Clin Biophys, Ljubljana, Slovenia

[35] Johannes Gutenberg Univ Mainz, Mol Cell Biol & Focus Program Translat Neurosci, D-55122 Mainz, Germany

[36] Finnish Red Cross Blood Serv, Res & Cell Serv, Helsinki, Finland

[37] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Krefting Res Ctr, Gothenburg, Sweden

[38] Semmelweis Univ, Dept Physiol, H-1085 Budapest, Hungary

[39] Latvian Biomed Res & Study Ctr, Riga, Latvia

[40] Univ Appl Sci & Arts Northwestern Switzerland, Sch Life Sci, Inst Chem & Bioanalyt, Muttenz, Switzerland

[41] Norwegian Radium Hosp, Inst Canc Res, Oslo Univ Hosp, Dept Mol Cell Biol, Oslo, Norway

[42] Natl Inst Chem, Biotechnol Lab, Ljubljana, Slovenia

[43] EN FIST Ctr Excellence, Ljubljana, Slovenia

[44] Univ Valencia, Fac Farm, Dept Biol Celular & Parasitol, E-46010 Valencia, Spain

[45] Ctr Nacl Invest Cardiovasc, Dept Vasc Biol & Inflammat, Madrid, Spain

[46] Univ Freiburg, Inst Environm Hlth Sci, D-79106 Freiburg, Germany

[47] Univ Freiburg, Hosp Infect ControlMed Ctr, D-79106 Freiburg, Germany

[48] Univ Utrecht, Fac Vet Med, Dept Biochem & Cell Biol, Utrecht, Netherlands

[49] Univ Helsinki, Inst Biotechnol, FI-00014 Helsinki, Finland

[50] Univ Dublin Trinity Coll, Sch Pharm & Pharmaceut Sci, Dublin 2, Ireland

来源：

JOURNAL OF EXTRACELLULAR VESICLES | 2015年 / 4卷

关键词：

extracellular vesicle; microvesicle; microparticle; exosome; physiology; prokaryote; eukaryote;

D O I：

10.3402/jev.v4.27066

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.

引用

页码：1 / 60

页数：60

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