NUCLEOLAR TRANSCRIPTION FACTOR HUBF CONTAINS A DNA-BINDING MOTIF WITH HOMOLOGY TO HMG PROTEINS

被引：614

作者：

JANTZEN, HM

ADMON, A

BELL, SP

TJIAN, R

机构：

[1] Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley

来源：

NATURE | 1990年 / 344卷 / 6269期

关键词：

D O I：

10.1038/344830a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The eukaryotic upstream binding factor (DBF), recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA poly-merase I through cooperative interactions with the species-specific factor, SL1. Isolation of complementary DNA clones and sequence analysis reveals similarities between DNA binding domains of human UBF (hUBF) and high mobility group (HMG) protein 1. Expression, cellular localization and in vitro transcription studies establish that cloned hUBF encodes a nucleolar factor that binds specifically to the upstream control element and core of the rRNA gene promoter to activate transcription in a binding site-dependent manner. © 1990 Nature Publishing Group.

引用

页码：830 / 836

页数：7

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