ISOLATION OF A BROMO ANALOG OF REBECCAMYCIN FROM SACCHAROTHRIX-AEROCOLONIGENES

被引：42

作者：

LAM, KS

SCHROEDER, DR

VEITCH, JM

MATSON, JA

FORENZA, S

机构：

[1] Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, CT 06492

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 09期

关键词：

D O I：

10.7164/antibiotics.44.934

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

When grown in a defined medium containing 0.05% KBr, Saccharothrix aerocolonigenes ATCC 39243 produces a novel bromo analog of rebeccamycin. This new analog, designated bromorebeccamycin, has been isolated from the culture broth and purified by vacuum liquid chromatography and column chromatography. Spectroscopic data demonstrated that bromorebeccamycin has the same structure as rebeccamycin, except for the replacement of the two chlorine atoms by bromine atoms in the molecule. Bromorebeccamycin and rebeccamycin have a similar potency and activity against P388 leukemia in the murine model.

引用

页码：934 / 939

页数：6

共 19 条

[1] ISOLATION OF BROMO ANALOGUES OF PYRROLNITRIN FROM PSEUDOMONAS PYRROLNITRICA
AJISAKA, M
KARIYONE, K
JOMON, K
YAZAWA, H
ARIMA, K
[J]. AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1969, 33 (02): : 294 - &
[2] BRADNER WT, 1980, CANCER CHEMOTHERAPY, V1, P221
[3] PRODUCTION AND BIOLOGICAL-ACTIVITY OF REBECCAMYCIN, A NOVEL ANTITUMOR AGENT
BUSH, JA
LONG, BH
CATINO, JJ
BRADNER, WT
[J]. JOURNAL OF ANTIBIOTICS, 1987, 40 (05) : 668 - 678
[4] X-RAY CRYSTAL-STRUCTURE OF STAUROSPORINE - NEW ALKALOID FROM A STREPTOMYCES STRAIN
FURUSAKI, A
HASHIBA, N
MATSUMOTO, T
HIRANO, A
IWAI, Y
OMURA, S
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1978, (18) : 800 - 801
[5] GERAN RI, 1972, CANC CHEMOTHER REP, V3, P1
[6] GOUREVITCH A, 1955, Antibiot Chemother (Northfield), V5, P448
[7] PREPARATION AND CHARACTERIZATION OF SOME BROMINE ANALOGS OF THE GLYCOPEPTIDE ANTIBIOTIC ACTAPLANIN
HUBER, FM
MICHEL, KH
HUNT, AH
MARTIN, JW
MOLLOY, RM
[J]. JOURNAL OF ANTIBIOTICS, 1988, 41 (06) : 798 - 801
[8] A NEW ANTIFUNGAL SUBSTANCE, BROMOMONILICIN, AND ITS PRECURSOR PRODUCED BY MONILINIA-FRUCTICOLA
KACHI, H
HATTORI, H
SASSA, T
[J]. JOURNAL OF ANTIBIOTICS, 1986, 39 (01) : 164 - 166
[9] K-252A, A POTENT INHIBITOR OF PROTEIN-KINASE-C FROM MICROBIAL ORIGIN
KASE, H
IWAHASHI, K
MATSUDA, Y
[J]. JOURNAL OF ANTIBIOTICS, 1986, 39 (08) : 1059 - 1065
[10] KASE H, 1986, J ANTIBIOT, V9, P1066

← 1 2 →