SEQUENCES OF THE COBALAMIN BIOSYNTHETIC GENES COBK, COBL AND COBM FROM RHODOCOCCUS SP NI86/21

被引：10

作者：

DEMOT, R

NAGY, I

SCHOOFS, G

VANDERLEYDEN, J

机构：

[1] F.A. Janssens Laboratory of Genetics, Catholic University of Leuven

来源：

GENE | 1994年 / 143卷 / 01期

关键词：

NOCARDIOFORM ACTINOMYCETE; VITAMIN-B-12; PSEUDOMONAS DENTRIFICANS; SALMONELLA TYPHIMURIUM; CBI GENES;

D O I：

10.1016/0378-1119(94)90610-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Sequence analysis of a 5753-bp genomic fragment of Rhodococcus sp. NI86/21 revealed the presence of three homologues of known cobalamin biosynthetic genes. One of these genes encodes a protein showing strong homology with the precorrin-6x reductase (CobK) of Pseudomonas dentrificans. In addition, the rhodococcal homologue of the corrin methyltransferases, CobM from P. dentrificans and CbiF from Salmonella typhimurium, was identified. The protein deduced from a third Rhodococcus gene aligns well with CobL of P. denitrificans and with the protein pair CbiE/CbiT of S. typhimurium, which are involved in corrin methylation and decarboxylation.

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页码：91 / 93

页数：3

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