SIMULTANEOUS-OPTIMIZATION OF CAPSULE AND TABLET FORMULATION USING RESPONSE-SURFACE METHODOLOGY

被引：24

作者：

ISKANDARANI, B ^{[1
]}

CLAIR, JH ^{[1
]}

PATEL, P ^{[1
]}

SHIROMANI, PK ^{[1
]}

DEMPSKI, RE ^{[1
]}

机构：

[1] TEMPLE UNIV,SCH PHARM,PHILADELPHIA,PA 19140

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1993年 / 19卷 / 16期

关键词：

D O I：

10.3109/03639049309069343

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The study described herein was undertaken to simultaneously optimize the composition of tablet and capsule formulation of an insoluble experimental drug, and to learn more about the effect of the interaction between the ingredients on the basic properties of the final dosage form. Four independent variables were varied in a set of statistically designed experiments, and a number of properties evaluated. A substantial saving in development time and quantity of drug was thereby achieved.

引用

页码：2089 / 2101

页数：13

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